饮食失调中T淋巴细胞胆囊收缩素-8和β-内啡肽浓度：I. 神经性厌食症

T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa.

作者信息

Brambilla F, Brunetta M, Peirone A, Perna G, Sacerdote P, Manfredi B, Panerai A E

机构信息

Centro di Psiconeuroendocrinologia, Ospedale Psichiatrico Pini, Milan, Italy.

出版信息

Psychiatry Res. 1995 Nov 29;59(1-2):43-50. doi: 10.1016/0165-1781(95)02664-9.

DOI:10.1016/0165-1781(95)02664-9

PMID:8771219

Abstract

Baseline concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) were measured in T-lymphocytes from 33 restricting patients with anorexia nervosa (AN-R), 23 binging/purging patients with anorexia nervosa (AN-BP), and 24 healthy volunteers. CCK-8 basal values were significantly lower and beta-EP values significantly higher in AN-R and AN-BP patients than in normal volunteers. Levels of the peptides were measured three more times during a 4-month combined cognitive-behavioral/psychopharmacological treatment (nortriptyline or fluoxetine in AN-R, fluoxetine or amineptine in AN-BP). CCK-8 values fluctuated (nonsignificantly) during each treatment, while beta-EP values decreased (to a significant degree only in fluoxetine-treated AN-R patients).

摘要

在33例限制型神经性厌食症（AN-R）患者、23例暴食/清除型神经性厌食症（AN-BP）患者以及24名健康志愿者的T淋巴细胞中测量了胆囊收缩素-8（CCK-8）和β-内啡肽（β-EP）的基线浓度。与正常志愿者相比，AN-R和AN-BP患者的CCK-8基础值显著更低，β-EP值显著更高。在为期4个月的认知行为/心理药物联合治疗期间（AN-R患者使用去甲替林或氟西汀，AN-BP患者使用氟西汀或阿米替林），又对这些肽的水平进行了三次测量。每次治疗期间CCK-8值有波动（无显著差异），而β-EP值下降（仅在接受氟西汀治疗的AN-R患者中有显著下降）。