Brambilla F, Brunetta M, Draisci A, Peirone A, Perna G, Sacerdote P, Manfredi B, Panerai A E
Psychoneuroendocrine Center, Ospedale Pini, Milan, Italy.
Psychiatry Res. 1995 Nov 29;59(1-2):51-6. doi: 10.1016/0165-1781(95)02674-6.
Concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline beta-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy.
测量了26名神经性贪食症（BN）女性患者及26名年龄和性别匹配的健康对照者T淋巴细胞中胆囊收缩素-8（CCK-8）和β-内啡肽（β-EP）的浓度。然后，10名患者口服氟伏沙明300mg/天，5名患者口服安咪奈丁300mg/天，治疗4个月。治疗1、2和4个月后再次测量这两种肽的浓度。患者的基础CCK-8值显著低于健康受试者。在氟伏沙明治疗期间，CCK-8值升高，到治疗第4个月时达到正常水平。安咪奈丁治疗期间未出现这种升高。神经性贪食症患者的基线β-EP值正常，但在氟伏沙明治疗第4个月时有所下降。
