Tepper R, Weizman A, Apter A, Tyano S, Beyth Y
Department of Obstetrics & Gynecology, Sapir Medical Center, Kfar Saba, Israel.
Clin Neuropharmacol. 1992 Oct;15(5):387-91. doi: 10.1097/00002826-199210000-00006.
Basal morning plasma levels of immunoreactive-beta-endorphin (ir-beta-EP), and 17-beta estradiol (E2) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-beta-EP was significantly higher (84%) in the AN patients when compared with the control subjects. The elevated plasma ir-beta-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.
对25名神经性厌食症（AN）青少年和24名健康对照者的基础早晨血浆免疫反应性β-内啡肽（ir-β-EP）和17-β雌二醇（E2）水平进行了评估。所有受试者至少6周未服用药物。与对照受试者相比，AN患者的ir-β-EP平均血浆水平显著更高（84%）。血浆ir-β-EP升高可能与AN患者的食欲抑制、禁食耐受性以及下丘脑性腺功能减退有关。
