Stevens F M, Lloyd R S, Geraghty S M, Reynolds M T, Sarsfield M J, Mcnicholl B, Fottrell P F, Wright R, Mccarthy C F
Psychol Med. 1977 May;7(2):259-63. doi: 10.1017/s0033291700029342.
To test the hypothesis of an association between schizophrenia and coeliac disease, the sera of 380 chronic schizophrenic in-patients in two mental hospitals in the West of Ireland have been screened for the presence of reticulin antibodies. Antibodies were found in 26 patients. Twenty-one of these patients were further studied by proximal duodenal mucosal biopsy. None of the biopsies showed the morphological and histological features found in untreated coeliac disease. The incidence of reticulin antibodies in schizophrenic patients and controls is similar. The findings of this study lead to the rejection of the hypothesis of a positive genetic relationship between schizophrenia and coeliac disease.
为验证精神分裂症与乳糜泻之间存在关联的假说，对爱尔兰西部两家精神病院的380名慢性精神分裂症住院患者的血清进行了网状纤维抗体筛查。在26名患者中发现了抗体。其中21名患者进一步接受了十二指肠近端黏膜活检。所有活检均未显示出未经治疗的乳糜泻所具有的形态学和组织学特征。精神分裂症患者和对照组中网状纤维抗体的发生率相似。本研究结果导致否定了精神分裂症与乳糜泻之间存在正向遗传关系的假说。
