乳糜泻患者及其亲属体内的网状纤维抗体。
Reticulin antibodies in patients with coeliac disease and their relatives.
作者信息
Stevens F M, Lloyd R, Egan-Mitchell B, Mylotte M J, Fottrell P F, Wright R, McNicholl B, McCarthy C F
出版信息
Gut. 1975 Aug;16(8):598-602. doi: 10.1136/gut.16.8.598.
Abstract
The sera of 69 index coeliac patients, 121 of their first-degree relatives, and 104 controls were screened for the presence of reticulin antibodies. Among the untreated coeliac patients 75% of adults and 93% of children had reticulin antibody in their serum. Reticulin antibody was not present in any adequately treated coeliac patient. Of the first-degree relatives, 21 were reticulin antibody positive; 17 of these were biopsied and 12 were shown to have coeliac disease. Sixty-five of the coeliac relatives who did not have reticulin antibodies in their sera were biopsied and two had coeliac disease. Of the 68 relatives and 63 controls with normal biopsies, five of the relatives and four of the controls were reticulin antibody positive.
摘要
对69例乳糜泻指数患者、121例其一级亲属以及104例对照者的血清进行网硬蛋白抗体筛查。在未经治疗的乳糜泻患者中，75%的成人和93%的儿童血清中有网硬蛋白抗体。任何经过充分治疗的乳糜泻患者血清中均无网硬蛋白抗体。在一级亲属中，21人网硬蛋白抗体呈阳性；其中17人接受了活检，12人被诊断为乳糜泻。65例血清中网硬蛋白抗体阴性的乳糜泻亲属接受了活检，其中2人患有乳糜泻。在68例活检正常的亲属和63例对照者中，5例亲属和4例对照者网硬蛋白抗体呈阳性。
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