Mallas E G, Williamson N, Cooper B T, Cooke W T
Gut. 1977 Aug;18(8):647-50. doi: 10.1136/gut.18.8.647.
IgA class reticulin antibodies were not found in patients with Crohn's disease, ulcerative colitis, and hiatus hernia despite a significant incidence of IgG class reticulin antibodies. None of 56 normal healthy subjects was positive. In contrast, 13 (76%) of the sera from 17 patients with coeliac disease on normal diet were positive for IgA class antibodies as were 19 (20%) of 93 first degree relatives. Seventy-three relatives underwent jejunal biopsy. Grade III (flat) histology was found in 13 and, of these patients, 10 (77%) showed IgA class reticulin antibody in their serum. It is suggested that determination of IgA class reticulin antibodies was a useful test to determine which relative must be biopsied.
尽管IgG类网状纤维抗体在克罗恩病、溃疡性结肠炎和食管裂孔疝患者中有显著的发生率，但未发现IgA类网状纤维抗体。56名正常健康受试者均为阴性。相比之下，17名正常饮食的乳糜泻患者中有13名（76%）血清IgA类抗体呈阳性，93名一级亲属中有19名（20%）呈阳性。73名亲属接受了空肠活检。13名患者出现III级（扁平）组织学表现，其中10名（77%）血清中显示有IgA类网状纤维抗体。有人提出，检测IgA类网状纤维抗体是确定哪些亲属必须接受活检的一项有用检测。
