Lei Z W, Wu S C, Garceau R J, Jiang S, Yang Q Z, Wang W L, Vander Meulen T C
Sichuan Reproductive Health Institute, Chengdu, PR China.
Contraception. 1996 Jun;53(6):357-61. doi: 10.1016/0010-7824(96)00085-6.
The study examined the effect of pretreatment counseling upon discontinuation of 150 mg depo-medroxyprogesterone acetate (Depo-Provera (DMPA)), given for contraception. A total of 421 Chinese women participated, 204 receiving detailed structured pretreatment and ongoing counseling on the hormonal effects and probable side effects of DMPA and 217 receiving only routine counseling. The primary study endpoint was termination rate; secondary endpoints were frequency of medical events and reasons for termination. Study termination rates were significantly lower in the intensive structured counseling group than in the routine counseling group. At one year, the total cumulative termination rates were 11% (23/204) and 42% (92/217), respectively (p < 0.0001). The most common reasons for terminating DMPA were menstrual changes. No pregnancy, serious or unexpected medical events were reported, nor were statistically or clinically significant changes in vital signs observed. We conclude that pretreatment counseling on expected side effects increases the acceptability of DMPA.
该研究考察了预处理咨询对停用用于避孕的150毫克醋酸甲羟孕酮（Depo-Provera，DMPA）的影响。共有421名中国女性参与，其中204名接受了关于DMPA激素作用及可能副作用的详细结构化预处理及持续咨询，217名仅接受常规咨询。主要研究终点是停用率；次要终点是医疗事件发生频率及停用原因。强化结构化咨询组的研究停用率显著低于常规咨询组。一年时，总累积停用率分别为11%（23/204）和42%（92/217）（p<0.0001）。停用DMPA最常见的原因是月经变化。未报告妊娠、严重或意外的医疗事件，生命体征也未观察到有统计学或临床意义的变化。我们得出结论，关于预期副作用的预处理咨询可提高DMPA的可接受性。
