Kimura M, Ujihara M, Yokoi K
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Japan.
Biol Trace Elem Res. 1996 May;52(2):171-9. doi: 10.1007/BF02789459.
To investigate the manganese status in magnesium deficiency, 40 male Wistar rats, 3 wk old, were divided into two groups and fed a magnesium deficient diet or a normal synthetic diet for 2 wk. Dietary magnesium depletion decreased magnesium levels in brain, spinal cord, lung, spleen, kidney, testis, bone, blood, and plasma, while it elevated the magnesium level in liver. In magnesium-depleted rats, calcium concentration was increased in lung, liver, spleen, kidney, and testis, while it was decreased in tibia. In magnesium-depleted rats, manganese concentration was decreased in plasma and all tissues except adrenal glands and blood. Dietary magnesium depletion diminished pyruvate carboxylase (EC 6.4.1.1) activity in the crude mitochondrial fraction of liver. Positive correlation was found between the liver manganese concentration and the pyruvate carboxylase activity. In the magnesium-depleted rats, glucose was decreased while plasma lipids (triglycerides, phospholipids, and total cholesterol) were increased. These results suggest that dietary magnesium deficiency changes manganese metabolism in rats.
为研究镁缺乏时的锰状态，将40只3周龄雄性Wistar大鼠分为两组，分别给予缺镁饮食或正常合成饮食2周。饮食中镁缺乏降低了脑、脊髓、肺、脾、肾、睾丸、骨骼、血液和血浆中的镁水平，而提高了肝脏中的镁水平。在缺镁大鼠中，肺、肝、脾、肾和睾丸中的钙浓度升高，而胫骨中的钙浓度降低。在缺镁大鼠中，血浆以及除肾上腺和血液外的所有组织中的锰浓度均降低。饮食中镁缺乏降低了肝脏粗线粒体部分的丙酮酸羧化酶（EC 6.4.1.1）活性。肝脏锰浓度与丙酮酸羧化酶活性之间存在正相关。在缺镁大鼠中，血糖降低而血浆脂质（甘油三酯、磷脂和总胆固醇）升高。这些结果表明，饮食中镁缺乏会改变大鼠的锰代谢。
