Nishimura N, Ogura C, Ohta I
Department of Neuropsychiatry, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Psychiatry Clin Neurosci. 1995 Mar;49(1):79-86. doi: 10.1111/j.1440-1819.1995.tb01863.x.
Effects of the dopamine-related drug bromocriptine (BCT) on event-related potentials (ERP) were investigated in 18 healthy volunteers. Bromocriptine 2.5 mg or an inactive placebo was administered according to a completely randomized double-blind, cross-over design. The ERP were recorded 3 h after medication was given. Although BCT prolonged the P300 latency, it had no effect on the amplitudes of the ERP components as a whole. Bromocriptine increased the latencies of N100, P200 and P300 in the respective short-latency subject group, and decreased the latency of N200 in the long-latency subject group. It increased the amplitude of N200 in the low-amplitude subject group. It was concluded that the prolongation of P300 latency as a whole and the different responses that take place are dependent on the initial values and were recognized in the effect of a single administration of BCT 2.5 mg. The results of this study are discussed in relation to the law of initial value.
在18名健康志愿者中研究了多巴胺相关药物溴隐亭（BCT）对事件相关电位（ERP）的影响。按照完全随机双盲交叉设计给予2.5毫克溴隐亭或无活性安慰剂。给药3小时后记录ERP。虽然BCT延长了P300潜伏期，但总体上对ERP各成分的波幅没有影响。溴隐亭在各自的短潜伏期受试者组中增加了N100、P200和P300的潜伏期，在长潜伏期受试者组中缩短了N200的潜伏期。它在低波幅受试者组中增加了N200的波幅。得出的结论是，P300潜伏期总体延长以及所发生的不同反应取决于初始值，并且在单次给予2.5毫克BCT的效应中得到体现。结合初始值定律对本研究结果进行了讨论。
