多巴胺D2受体（DRD2）和多巴胺转运体（DAT1）基因多态性与分裂样/回避行为（SAB）的关联。
Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB).
作者信息
Blum K, Braverman E R, Wu S, Cull J G, Chen T J, Gill J, Wood R, Eisenberg A, Sherman M, Davis K R, Matthews D, Fischer L, Schnautz N, Walsh W, Pontius A A, Zedar M, Kaats G, Comings D E
机构信息
UTHSC School of Public Health at Houston, Department of Behavioral Sciences, San Antonio 78284-7976, USA.
出版信息
Mol Psychiatry. 1997 May;2(3):239-46. doi: 10.1038/sj.mp.4000261.
The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D2 receptor Taq A1 allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT1) gene with SAB was similarly found.
多巴胺能系统，尤其是多巴胺D2受体，与大脑中的奖赏机制有关。D2多巴胺受体功能障碍会导致异常的物质寻求行为（乙醇、药物、烟草和食物）以及其他相关行为（病理性赌博、妥瑞氏症、注意力缺陷多动障碍）。这是第一项支持多巴胺D2受体Taq A1等位基因与分裂样/回避行为（SAB）之间存在强关联的研究。此外，同样发现多巴胺转运体（DAT1）基因480-bp可变数目串联重复序列10/10等位基因与SAB之间存在较弱的关联。
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