List M A, Ritter-Sterr C A, Baker T M, Colangelo L A, Matz G, Pauloski B R, Logemann J A
University of Chicago Cancer Research Center, IL 60637, USA.
Head Neck. 1996 Jan-Feb;18(1):1-10. doi: 10.1002/(SICI)1097-0347(199601/02)18:1<1::AID-HED1>3.0.CO;2-7.
Although quality of life (QL) and performance status are important outcomes in head and neck (HN) cancer, there is little systematic inclusion of these parameters in treatment trials.
Rate and recovery of function were evaluated over a 6-month period in 21 laryngeal cancer patients, 7 in each of 3 treatment groups: total laryngectomy (group 1), hemilaryngectomy (group 2), and radiotherapy only (group 3). Assessment included Performance Status Scale for Head and Neck Cancer Patients (PSS-HN: Diet, Speech, and Eating in Public subscales) and the FACT-HN, a multidimensional QL measure.
Groups differed in patterns of performance recovery over time in expected directions. Group 1 recovered most slowly, without achieving normal functioning by 6 months; most of group 2 returned to normal functioning by 3 months; group 3 showed little overall dysfunction. There was no difference in overall QL between groups or over time. Performance status was significantly correlated with the FACT head and neck subscale and somewhat with the Physical subscale. In contrast, ability to eat and/or speak was not associated with overall QL nor with any other specific QL dimension (eg, emotional or social well-being).
Results support the sensitivity and applicability of two site-specific performance/QL measures: PSS-HN and FACT-HN. Findings also emphasize the need to employ multidimensional tools to adequately evaluate the nonmedical outcomes in head and neck patients.
尽管生活质量（QL）和体能状态是头颈（HN）癌的重要预后指标，但在治疗试验中很少系统纳入这些参数。
对21例喉癌患者在6个月期间的功能恢复率和恢复情况进行评估，3个治疗组每组7例：全喉切除术（第1组）、半喉切除术（第2组）和单纯放疗（第3组）。评估包括头颈癌患者体能状态量表（PSS-HN：饮食、言语和公共场合进食子量表）以及FACT-HN，一种多维生活质量测量方法。
各组在预期方向上随时间的体能恢复模式有所不同。第1组恢复最慢，6个月时未恢复到正常功能；第2组大多数患者在3个月时恢复到正常功能；第3组总体功能障碍较小。各组之间以及随时间推移，总体生活质量没有差异。体能状态与FACT头颈子量表显著相关，与身体子量表有一定相关性。相比之下，进食和/或说话能力与总体生活质量以及任何其他特定生活质量维度（如情感或社会幸福感）均无关联。
结果支持两种特定部位的体能/生活质量测量方法（PSS-HN和FACT-HN）的敏感性和适用性。研究结果还强调需要采用多维工具来充分评估头颈患者的非医学预后。
