Does physical activity reduce risk of estrogen-dependent cancer in women?

The estrogen-dependent cancers (breast, endometrial, and ovarian) are among the leading causes of morbidity and mortality in American women. Increased incidence of these cancers is predicted in the future, and the need for primary prevention is clear. Sufficient evidence has accumulated to warrant an analysis of the relationship between physical activity and estrogen-dependent cancer. Recent epidemiological studies confirm an inverse relationship between physical activity and estrogen-dependent cancer, with stronger associations appearing for occupational activity than for leisure time or nonoccupational activity. Several hypothesized mechanisms are described for the prevention of estrogen-dependent cancer by physical activity: 1) maintenance of low body fat and moderation of extraglandular estrogen, 2) reduction in number of ovulatory cycles and subsequent diminution of lifetime exposure to endogenous estrogen, 3) enhancement of natural immune function, and 4) the association of other healthy lifestyle habits. Although the mechanisms are not well defined, several lines of evidence support the inclusion of low-to-moderate physical activity as a preventive strategy for estrogen-dependent cancer.