阿基坦地区艾滋病毒感染患者中丙型肝炎病毒抗体的流行情况及决定因素和乙型肝炎病毒感染标志物。阿基坦地区艾滋病临床流行病学小组。

Prevalence and determinants of antibodies to hepatitis C virus and markers for hepatitis B virus infection in patients with HIV infection in Aquitaine. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.

作者信息

Saillour F, Dabis F, Dupon M, Lacoste D, Trimoulet P, Rispal P, Monlun E, Ragnaud J M, Morlat P, Pellegrin J L, Fleury H, Couzigou P

机构信息

Unité INSERM No 330, Université de Bordeaux II, France.

出版信息

BMJ. 1996 Aug 24;313(7055):461-4. doi: 10.1136/bmj.313.7055.461.

DOI:10.1136/bmj.313.7055.461

PMID:8776313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2351885/

Abstract

OBJECTIVE

To evaluate the prevalence of antibodies to hepatitis C virus and serological markers for hepatitis B virus infection in patients with HIV.

DESIGN

Cross sectional survey.

SETTING

Aquitaine, southwestern France, 1991-94.

SUBJECTS

1935 HIV positive patients seen at least once since June 1991.

MAIN OUTCOME MEASURES

Presence of antibodies to hepatitis C virus were detected by second or third generation enzyme linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA) and markers for hepatitis B virus detected by ELISA.

RESULTS

The prevalence was 42.5% (823) for antibodies to hepatitis C virus, 56.4 (507) for antibodies to hepatitis B core antigen, 6.9% (133) for hepatitis B surface antigen, 30.2% (584) for antibodies to hepatitis B core and surface antigen with no detectable surface antigen, 26.2% (507) for antibodies to core antigen only, and 4.8% (92) for antibodies to surface antigen only. The prevalence of antibodies to hepatitis C virus was 86.1% (726/843) in subjects who had bloodborne HIV infection and 7.3% (66/899) in those with sexually acquired infection. The prevalence of markers for hepatitis B was higher among homosexuals than in the other groups of patients, except for antibodies to surface antigen alone. The relation between markers for hepatitis B and hepatitis C virus was negative among men but positive among women.

CONCLUSIONS

The results favour the hypothesis that hepatitis C virus is sexually transmitted much less commonly than either HIV or hepatitis B virus.

摘要

目的

评估人类免疫缺陷病毒（HIV）感染者中丙型肝炎病毒抗体及乙型肝炎病毒感染血清学标志物的流行情况。

设计

横断面调查。

地点

法国西南部阿基坦，1991 - 1994年。

研究对象

自1991年6月起至少就诊过一次的1935例HIV阳性患者。

主要观察指标

采用第二代或第三代酶联免疫吸附试验（ELISA）及重组免疫印迹试验（RIBA）检测丙型肝炎病毒抗体，采用ELISA检测乙型肝炎病毒标志物。

结果

丙型肝炎病毒抗体流行率为42.5%（823例），乙型肝炎核心抗原抗体流行率为56.4%（507例），乙型肝炎表面抗原流行率为6.9%（133例），乙型肝炎核心及表面抗原抗体且表面抗原检测不到的流行率为30.2%（584例），仅核心抗原抗体流行率为26.2%（507例），仅表面抗原抗体流行率为4.8%（92例）。经血液传播HIV感染的患者中丙型肝炎病毒抗体流行率为86.1%（726/843），性传播感染患者中为7.3%（66/899）。除仅表面抗原抗体外，同性恋患者中乙型肝炎标志物的流行率高于其他患者组。乙型肝炎标志物与丙型肝炎病毒之间的关系在男性中为负相关，在女性中为正相关。