Lewis B E, Iaffaldano R, McKiernan T L, Rao L, Donkin J, Wallenga J M
Department of Cardiology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Cathet Cardiovasc Diagn. 1996 Jun;38(2):206-9. doi: 10.1002/(SICI)1097-0304(199606)38:2<206::AID-CCD20>3.0.CO;2-F.
Heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) is a severe complication of heparin caused by an antibody response to the heparin-platelet factor 4 complex which results in severe thrombosis. Heparin rechallenge in HITTS patients carries a high risk of inducing thrombosis. Antithrombin agents represent treatment alternatives in HITTS patients who require anticoagulation. We report successful coronary stent implantation in a HITTS patient using the antithrombin agent argatroban.
肝素诱导的血小板减少症和血栓形成综合征（HITTS）是肝素的一种严重并发症，由针对肝素-血小板因子4复合物的抗体反应引起，可导致严重血栓形成。HITTS患者再次使用肝素会有诱发血栓形成的高风险。对于需要抗凝治疗的HITTS患者，抗凝血酶药物是替代治疗选择。我们报告了一例使用抗凝血酶药物阿加曲班成功为HITTS患者植入冠状动脉支架的病例。
