Hilker E, Domschke W, Stoll R
Department of Internal Medicine B, University of Münster, Germany.
J Physiol Pharmacol. 1996 Mar;47(1):79-90.
The urea breath test (UBT) reflects the intragastric urease activity and thus the extent of H. pylori (H.p.) burden of the mucosa. We compared UBT results with gastroscopic and histologic findings in 174 patients. H.p.density, grade and activity of the chronic gastritis type B were semiquantitatively assessed. 46% of patients were H.p.-positive. A type B gastritis was significantly (p < 0.01) associated with H.p. colonization. UBT-results significantly correlated with the grade (r = 0.53) and the activity (r = 0.45) of gastritis. They correlated better with grade and activity of the inflammation than did the H.p.-density in histology (r = 0.38 and r = 0.37). There is a considerable interindividual variability in UBT-results for the same degree of gastritis indicating that besides the number of bacteria other factors must be of significance for the severity of inflammation. Endoscopic findings apart from ulcers do not predict the presence of H.p.
尿素呼气试验（UBT）反映胃内脲酶活性，进而反映黏膜幽门螺杆菌（H.p.）感染负担的程度。我们比较了174例患者的UBT结果与胃镜及组织学检查结果。对B型慢性胃炎的H.p.密度、分级及活动度进行了半定量评估。46%的患者H.p.呈阳性。B型胃炎与H.p.定植显著相关（p < 0.01）。UBT结果与胃炎的分级（r = 0.53）及活动度（r = 0.45）显著相关。与组织学检查中的H.p.密度（r = 0.38和r = 0.37）相比，UBT结果与炎症分级及活动度的相关性更好。对于相同程度的胃炎，UBT结果存在相当大的个体间差异，这表明除细菌数量外，其他因素对炎症严重程度也具有重要意义。除溃疡外，内镜检查结果无法预测H.p.的存在情况。
