Tavernor S J, Brown S W, Tavernor R M, Gifford C
David Lewis Centre, Cheshire, England.
Seizure. 1996 Mar;5(1):79-83. doi: 10.1016/s1059-1311(96)80067-7.
EEG with co-registered electrocardiography was recorded during at least two interictal epileptiform EEG discharges in each of 11 patients who later suffered from sudden unexpected death in epilepsy (SUDEP), and from another 11 age and sex matched patients, also with uncontrolled tonic-clonic seizures, drawn from the same centre who were still alive at the time of investigation (non-SUDEPs). A corrected QT interval for rate (QTc) was obtained and a mean value calculated for the period immediately prior to discharge, during discharge and immediately post discharge. Mean QTc was also obtained interictally without discharge. There was a significant (P = 0.01) increase in the mean QTc during discharge compared to that measured interictally without discharge for the whole population of SUDEPs and non-SUDEPs, and this was maintained for the SUDEPs alone (P = 0.02) but did not hold for the non-SUDEP group alone. Although reaching statistical significance, increases in mean QTc in SUDEP patients only exceeded currently accepted upper limits in one case, and then only marginally. The clinical significance of these findings merits further investigation.
对11例后来死于癫痫性猝死（SUDEP）的患者以及另外11例年龄和性别匹配、同样患有无法控制的强直阵挛性发作且在调查时仍存活的患者（非SUDEP患者），在每次至少两次发作间期癫痫样脑电图放电期间记录了脑电图并同步记录心电图。计算出心率校正QT间期（QTc），并得出放电前即刻、放电期间和放电后即刻的平均值。还在发作间期无放电时获取了平均QTc。与在发作间期无放电时测量的值相比，SUDEP患者和非SUDEP患者总体在放电期间的平均QTc有显著增加（P = 0.01），且仅SUDEP患者的这种增加得以维持（P = 0.02），而非SUDEP组单独不存在这种情况。虽然达到了统计学显著性，但SUDEP患者平均QTc的增加仅在1例中超过了目前公认的上限，且仅略超。这些发现的临床意义值得进一步研究。
