Williams B D, Pussell B A, Lockwood C M, Cotton C
Lancet. 1979 Jun 23;1(8130):1311-4. doi: 10.1016/s0140-6736(79)91947-0.
The function of the splenic reticuloendothelial system in patients with rheumatoid arthritis (R.A.) was assessed by determining the clearance of autologous heat-damaged erythrocytes from the circulation. 11/13 patients with active R.A. had a defect in the clearance of red cells and there was a significant inverse correlation between splenic function and the level of circulating immune complexes detected by a Clq-binding assay. Splenic function was normal in 13 patients with inactive disease who had been treated with either gold or prednisone. A serial study on 1 patient with active R.A. showed a clear correlation between fluctuations in disease activity, splenic function, and the level of circulating immune complexes.
通过测定循环中自体热损伤红细胞的清除率，评估类风湿性关节炎（R.A.）患者脾网状内皮系统的功能。13例活动期R.A.患者中有11例存在红细胞清除缺陷，并且通过Clq结合试验检测到的脾功能与循环免疫复合物水平之间存在显著的负相关。13例接受金制剂或泼尼松治疗的非活动期疾病患者的脾功能正常。对1例活动期R.A.患者的系列研究表明，疾病活动度波动、脾功能和循环免疫复合物水平之间存在明显的相关性。
