Murphy D J, Hope P L, Johnson A
National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford.
Arch Dis Child Fetal Neonatal Ed. 1996 Mar;74(2):F105-9. doi: 10.1136/fn.74.2.f105.
To investigate the incidence and timing of neonatal ultrasound lesions, and clinical details about pregnancy and the perinatal period, in a total population of extremely premature children with cerebral palsy, born to mothers who were resident in Oxfordshire.
Eighteen children born at less than 32 completed weeks of gestation were identified from a regional cerebral palsy register. Eighteen controls were matched for gestation, time, and place of birth. Perinatal records and ultrasound reports were systematically reviewed. Sequential neonatal ultrasound images stored on videotape were reanalysed, blind to the outcome of the infants.
Sixteen (89%) of the cerebral palsy cases and one (6%) control had parenchymal cysts on neonatal brain scans. Of the cerebral palsy cases, none had cysts detectable on the first day. Six developed cysts within the first 10 days of life, and two of these had periventricular echodensities when first scanned postnatally. Antenatal complications were recorded in 16 cases and nine controls. The early postnatal appearance of cysts in a few babies with a history of severe antenatal complications suggested that antenatal factors may have contributed to the cerebral pathology.
Intrauterine factors may have contributed to adverse neurological outcome, but 16/18 of the preterm cerebral palsy cases had an associated cerebral lesion which developed in the perinatal period.
调查牛津郡常住母亲所生的极早产脑瘫患儿群体中新生儿超声病变的发生率和发生时间，以及妊娠和围产期的临床细节。
从地区脑瘫登记册中确定18名妊娠不足32周的患儿。选取18名对照，在妊娠周数、出生时间和地点方面进行匹配。系统回顾围产期记录和超声报告。对录像带上存储的系列新生儿超声图像进行重新分析，分析人员对婴儿的结局不知情。
16例（89%）脑瘫患儿和1例（6%）对照在新生儿脑部扫描时有实质囊肿。在脑瘫患儿中，出生第一天均未检测到囊肿。6例在出生后10天内出现囊肿，其中2例出生后首次扫描时伴有脑室周围回声增强。16例患儿和9例对照记录有产前并发症。少数有严重产前并发症病史的婴儿出生后早期出现囊肿，提示产前因素可能与脑部病变有关。
宫内因素可能导致不良神经结局，但18例早产脑瘫患儿中有16例在围产期出现相关脑部病变。
