Sci Prog. 2018 Oct 1;101(4):332-359. doi: 10.3184/003685018X15360040523721. Epub 2018 Oct 8.
Nutritionally, the first 1,000 days of an infant's life - from conception to two years - has been identified as a highly influential period, during which lasting health can be achieved. Significant evidence links patterns of infant feeding to both short and long-term health outcomes, many of which can be prevented through nutritional modifications. Recommended globally, breastfeeding is recognised as the gold standard of infant nutrition; providing key nutrients to achieve optimal health, growth and development, and conferring immunologic protective effects against disease. Nevertheless, infant formulas are often the sole source of nutrition for many infants during the first stage of life. Producers of infant formula strive to supply high quality, healthy, safe alternatives to breast milk with a comparable balance of nutrients to human milk imitating its composition and functional performance measures. The concept of 'nutritional programming', and the theory that exposure to specific conditions, can predispose an individual's health status in later life has become an accepted dictum, and has sparked important nutritional research prospects. This review explores the impact of early life nutrition, specifically, how different feeding methods affect health outcomes.
在营养方面,婴儿生命的前 1000 天(从受孕到两岁)被确定为一个高度影响的时期,可以在此期间实现持久的健康。大量证据表明,婴儿喂养模式与短期和长期健康结果都有关联,其中许多结果可以通过营养调整来预防。全球推荐母乳喂养是婴儿营养的黄金标准;提供关键营养素以实现最佳健康、生长和发育,并赋予免疫保护作用以预防疾病。然而,在生命的第一阶段,婴儿配方奶粉通常是许多婴儿的唯一营养来源。婴儿配方奶粉的生产者努力提供高质量、健康、安全的替代品,以母乳为参照,具有可比的营养平衡,模仿其组成和功能性能指标。“营养编程”的概念,以及接触特定条件可以使个体在以后的生活中易患健康状况的理论,已成为公认的格言,并引发了重要的营养研究前景。本综述探讨了早期营养的影响,特别是不同喂养方式如何影响健康结果。