Foster B S, Mukai S
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.
Int Ophthalmol Clin. 1996 Winter;36(1):153-60. doi: 10.1097/00004397-199603610-00016.
In the pediatric population, retinoblastoma must be included in the differential diagnosis of intraocular or orbital inflammation, especially if the case is atypical of unresponsive to medical therapy. Diffuse infiltrating retinoblastoma, a rare subtype of retinoblastoma, often presents as unilateral intraocular inflammation, usually occurs in older children, and may contain insufficient calcification for detection by CT scan. Orbital inflammatory signs may also be associated with intraocular retinoblastoma. The clinician must perform a thorough ocular examination in these cases with the suspicion of retinoblastoma. He or she must also understand the subtleties of noninvasive imaging in such cases. The goal is to diagnose this tumor more accurately and expediently so that treatment and counseling can be provided without delay.
在儿科人群中，视网膜母细胞瘤必须纳入眼内或眼眶炎症的鉴别诊断中，尤其是当病例不典型或对药物治疗无反应时。弥漫性浸润性视网膜母细胞瘤是视网膜母细胞瘤的一种罕见亚型，常表现为单侧眼内炎症，通常发生于年龄较大的儿童，且可能钙化不足，CT扫描难以检测到。眼眶炎症体征也可能与眼内视网膜母细胞瘤相关。临床医生在怀疑视网膜母细胞瘤的这些病例中必须进行全面的眼部检查。他或她还必须了解此类病例中非侵入性成像的细微之处。目标是更准确、更迅速地诊断这种肿瘤，以便能够立即提供治疗和咨询。
