Chynn E W, Jakobiec F A
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.
Int Ophthalmol Clin. 1996 Winter;36(1):61-72. doi: 10.1097/00004397-199603610-00008.
Cogan's syndrome is an idiopathic inflammatory disease which may present as interstitial keratitis, inflammation of other ocular structures, Meniere's-like attacks, or systemic vasculitis. Although the ocular manifestations respond to topical steroids and are rarely serious, permanent deafness may result if systemic steroid therapy is not promptly instituted for audiovestibular dysfunction, while major morbidity and even death may occur if systemic sequelae such as vasculitis and aortic insufficiency are not recognized. For these reasons, ophthalmologists must suspect Cogan's syndrome in any patient presenting with ocular inflammation who develops hearing loss, vertigo, ataxia, tinnitus, systemic vasculitis, or aortic insufficiency.
科根综合征是一种特发性炎症性疾病，可表现为间质性角膜炎、其他眼部结构炎症、梅尼埃样发作或系统性血管炎。虽然眼部表现对局部类固醇治疗有反应且很少严重，但如果不及时对听觉前庭功能障碍进行全身类固醇治疗，可能会导致永久性耳聋，而如果未识别出血管炎和主动脉瓣关闭不全等全身后遗症，则可能会发生严重的发病甚至死亡。由于这些原因，眼科医生必须怀疑任何出现眼部炎症且伴有听力丧失、眩晕、共济失调、耳鸣、系统性血管炎或主动脉瓣关闭不全的患者患有科根综合征。
