Ho A C, Roat M I, Venbrux A, Hellmann D B
Department of Medicine, The Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
J Rheumatol. 1999 Jun;26(6):1404-7.
Cogan's syndrome is a rare multisystem disease characterized by ocular inflammation, vestibuloauditory dysfunction, and vasculitis. We report a 26-year-old Caucasian woman who died from Cogan's syndrome. Her case illustrates that patients with Cogan's syndrome can have abdominal aortitis and mesenteric vasculitis, and that the vasculitis can be refractory to methotrexate, cyclophosphamide, cyclosporine, and chlorambucil.
科根综合征是一种罕见的多系统疾病，其特征为眼部炎症、前庭听觉功能障碍和血管炎。我们报告了一名死于科根综合征的26岁白人女性。她的病例表明，科根综合征患者可出现腹主动脉炎和肠系膜血管炎，且这种血管炎对甲氨蝶呤、环磷酰胺、环孢素和苯丁酸氮芥治疗无效。
