Barton R T, Ucmakli A
Surg Gynecol Obstet. 1977 Jul;145(1):21-7.
Treatment of 88 selected patients with Stages I and II squamous cell carcinoma of the floor of the mouth by monobloc resection has produced a high five year cure rate. The death of one patient in the series postoperatively was considered a surgical one. Disability after such a procedure is minimal, and dental complications are not a factor. Elective irradiation of the neck is recommended in those instances of positive sublingual or submandibular nodes found in the monobloc specimen and in all patients with Stages III and IV lesions. Radiation therapy is recommended for highly anaplastic neoplasms, for instances when speech impairment is important, for lesions in the posterior limits of the floor of the mouth, for edentulous patients without bone invasion, for the treatment of recurrent lesions after operation and for synchronous multiple primary carcinomas of the head and neck if one of which is a carcinoma of the floor of the mouth.
对88例经选择的I期和II期口底鳞状细胞癌患者进行整块切除术，已取得了较高的五年治愈率。该系列中有1例患者术后死亡被认为是手术所致。这种手术后的残疾程度极小，且牙齿并发症不是一个影响因素。对于整块切除标本中发现舌下或下颌下淋巴结阳性的病例以及所有III期和IV期病变的患者，建议对颈部进行选择性放疗。对于高度间变的肿瘤、当言语障碍很重要时、对于口底后部界限的病变、对于无骨侵犯的无牙患者、对于术后复发病变的治疗以及对于头颈部同步多原发癌（其中之一为口底癌），建议进行放射治疗。
