Yutani Y, Minato Y, Hirata K, Syoji A, Yamano Y
Department of Orthopedics, Osaka City University Medical School, Japan.
Osaka City Med J. 1995 Dec;41(2):85-9.
Sarcoidosis shows many of the clinical and immunological abnormalities and is a multi-organ granulomatous disease of unknown cause which has histological features of non-caseous epithelioid granuloma formation. Sarcoidosis is rarely coexisted rheumatoid arthritis. Although such arthropathy if occur is thought to manifest rheumatoid changes, the current presence of sarcoidosis and rheumatoid arthropathy has been reported by very few histological studies. We experienced a case of combination of sarcoidosis and rheumatoid arthritis both of which were histologically confirmed. This patient initially developed small papules on the face and was diagnosed as having sarcoidosis after one year. Later, she showed symptoms and signs of polyarthritis and was confirmed to have sarcoidosis and rheumatoid arthritis in combination by histological analysis. We present this case with some reference to literatures.
结节病呈现出许多临床和免疫学异常，是一种病因不明的多器官肉芽肿性疾病，具有非干酪样上皮样肉芽肿形成的组织学特征。结节病很少与类风湿性关节炎共存。尽管这种关节病如果发生被认为会表现出类风湿性改变，但目前很少有组织学研究报道结节病和类风湿性关节病同时存在的情况。我们遇到了一例经组织学证实的结节病与类风湿性关节炎合并的病例。该患者最初面部出现小丘疹，一年后被诊断为结节病。后来，她出现了多关节炎的症状和体征，经组织学分析确诊为结节病与类风湿性关节炎合并。我们结合一些文献介绍此病例。
