Modiano D, Petrarca V, Sirima B S, Bosman A, Nebié I, Diallo D, Lamizana L, Esposito F, Coluzzi M
Istituto di Parassitologia, W.H.O. Collaborating Centre for Malaria Epidemiology, Università La Sapienza, Roma, Italy.
Parassitologia. 1995 Dec;37(2-3):255-9.
Plasmodium falciparum parasite rate, parasite density and anti-CS antibodies were assessed in 196 subjects (age > 10 yrs) belonging to three sympatric West African ethnic groups, namely Mossi, Rimaibé and Fulani, all exposed to very high seasonal malaria transmission in the same rural village near Ouagadougou, Burkina Faso. No interethnic differences were noted in the use of antimalaria measures nor in the exposure to malaria vectors. However, interethnic differences were found in each of the three malariological indices. The Fulani appeared markedly less parasitized and more responsive to the CS-antigen than the Mossi and the Rimaibé who had very similar indices, except in the case of parasite density. These findings suggest a higher resistance to malaria of the Fulani ethnic group, possibly involving human genetic factors and/or the influence of extrinsic variables (e.g., socio-cultural) among which diet differences should be considered.
在布基纳法索瓦加杜古附近的同一个乡村，对属于三个同域西非族群（即莫西族、里马贝族和富拉尼族）的196名年龄大于10岁的受试者进行了恶性疟原虫感染率、寄生虫密度和抗环子孢子蛋白（CS）抗体的评估，所有受试者都暴露于非常高的季节性疟疾传播环境中。在抗疟疾措施的使用或接触疟疾媒介方面未发现族群间差异。然而，在这三项疟疾学指标中的每一项都发现了族群间差异。富拉尼族的寄生虫感染率明显低于莫西族和里马贝族，并且对CS抗原的反应更强，莫西族和里马贝族的指标非常相似，但寄生虫密度情况除外。这些发现表明富拉尼族群对疟疾具有更高的抵抗力，这可能涉及人类遗传因素和/或外部变量（如社会文化）的影响，其中饮食差异应予以考虑。
