成人T细胞白血病/淋巴瘤患者及其兄弟姐妹和母亲中原发性恶性肿瘤的高发生率。

High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers.

作者信息

Kozuru M, Uike N, Muta K, Goto T, Suehiro Y, Nagano M

机构信息

Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan.

出版信息

Cancer. 1996 Sep 1;78(5):1119-24. doi: 10.1002/(SICI)1097-0142(19960901)78:5<1119::AID-CNCR24>3.0.CO;2-4.

DOI:10.1002/(SICI)1097-0142(19960901)78:5<1119::AID-CNCR24>3.0.CO;2-4

PMID:8780552

Abstract

BACKGROUND

Attempts were made to clarify the correlation between human T-cell leukemia/lymphoma virus (HTLV)-1 infection and malignant oncogenicity other than adult T-cell leukemia/lymphoma (ATL) in a case-control study.

METHODS

The occurrence of primary malignant neoplasms (MN) in 110 ATL patients, their parents, and 430 siblings was compared with HTLV-1 seronegative non-Hodgkin's lymphoma (NHL) patients, their parents and 867 siblings. The chi-square test, odds ratio (OR), and 95% confidence intervals (CI) were used to determine the statistical significance of differences in the occurrence of the primary MN among ATL patients, HTLV-1 seronegative NHL patients, their siblings, and their parents.

RESULTS

The occurrence of primary MN in the ATL patients was higher than the occurrence in HTLV-1 seronegative NHL patients (P = 0.0036; OR = 2.91; 95% CI: 1.42, 6.02). In siblings of the ATL patients, there was a higher occurrence of primary MN than in siblings of the HTLV-1 seronegative NHL patients (P < 0.0001; OR = 3.35; 95% CI: 2.01, 5.58). In mothers of the ATL patients, there was a higher occurrence of primary MN than in mothers of the HTLV-1 seronegative NHL patients (P = 0.0063; OR = 2.55; 95% CI: 1.30, 5.00), but not in fathers (P = 0.1602; OR = 1.68; 95% CI: 0.81, 3.47).

CONCLUSIONS

There is an increased risk of primary MN in ATL patients, their siblings, and their mothers.

摘要

背景

在一项病例对照研究中，人们试图阐明人类T细胞白血病/淋巴瘤病毒（HTLV）-1感染与除成人T细胞白血病/淋巴瘤（ATL）之外的恶性致癌性之间的相关性。

方法

将110例ATL患者、他们的父母以及430名兄弟姐妹中原发性恶性肿瘤（MN）的发生率，与HTLV-1血清学阴性的非霍奇金淋巴瘤（NHL）患者、他们的父母以及867名兄弟姐妹进行比较。采用卡方检验、比值比（OR）和95%置信区间（CI）来确定ATL患者、HTLV-1血清学阴性的NHL患者、他们的兄弟姐妹以及他们的父母中原发性MN发生率差异的统计学显著性。

结果

ATL患者中原发性MN的发生率高于HTLV-1血清学阴性的NHL患者（P = 0.0036；OR = 2.91；95% CI：1.42，6.02）。在ATL患者的兄弟姐妹中，原发性MN的发生率高于HTLV-1血清学阴性的NHL患者的兄弟姐妹（P < 0.0001；OR = 3.35；95% CI：2.01，5.58）。在ATL患者的母亲中，原发性MN的发生率高于HTLV-1血清学阴性的NHL患者的母亲（P = 0.0063；OR = 2.55；95% CI：1.30，5.00），但在父亲中无此差异（P = 0.1602；OR = 1.68；95% CI：0.81，3.47）。