Hou F Y, Coe C L, Erickson C
Harlow Primate Laboratory, University of Wisconsin-Madison 53715, USA.
J Neuroimmunol. 1996 Aug;68(1-2):13-8. doi: 10.1016/0165-5728(96)00055-0.
To evaluate cellular changes in the intrathecal compartment in response to psychological stress, cerebrospinal fluid (CSF) and peripheral blood (PB) samples were obtained from rhesus monkeys under baseline and challenge conditions. Juvenile monkeys separated from their social companions overnight had elevated cortisol, increased polymorphonuclear (PMN), and fewer CD4+ and CD8+ leukocytes in PB. In contrast, in CSF there were more CD4+ and fewer CD8+ leukocytes, raising the CD4/CD8 ratio. Dexamethasone given intramuscularly caused similar hematological changes; i.e. neutrophilia and lymphocytopenia with fewer CD4+ and CD8+ leukocytes in PB. However, it did not induce similar changes in CSF, indicating that the stress-related shift of CD4+ leukocytes in the intrathecal compartment involves physiological processes beyond adrenocortical steroids.
为评估鞘内间隙对心理应激的细胞变化反应，在基线和激发条件下从恒河猴获取脑脊液（CSF）和外周血（PB）样本。与社会同伴分离过夜的幼年猴子皮质醇升高，外周血中多形核细胞（PMN）增加，CD4⁺和CD8⁺白细胞减少。相比之下，脑脊液中有更多的CD4⁺白细胞和更少的CD8⁺白细胞，使CD4/CD8比值升高。肌肉注射地塞米松引起类似的血液学变化，即外周血中性粒细胞增多和淋巴细胞减少，CD4⁺和CD8⁺白细胞减少。然而，它并未在脑脊液中诱导类似变化，表明鞘内间隙中与应激相关的CD4⁺白细胞转移涉及肾上腺皮质类固醇以外的生理过程。
