异嗜色菌素I和II，由多色青霉FO-2338产生的新型抗gp120-CD4结合抑制剂。II. 结构解析。

Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation.

作者信息

Matsuzaki K, Tanaka H, Omura S

机构信息

School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1995 Jul;48(7):708-13. doi: 10.7164/antibiotics.48.708.

DOI:10.7164/antibiotics.48.708

PMID:7649872

Abstract

The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3,5-dimethyl-1,3-heptadien at C-3. Additionally, isochromophilone I has a gamma-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a gamma-lactone ring.

摘要

从多色青霉FO - 2338培养 broth中分离得到的新型gp120 - CD4结合抑制剂异嗜色菌素I和II的结构，通过核磁共振实验得以阐明。这两种化合物均具有一个在C - 5位被氯原子取代的氮杂环庚三烯酮骨架以及一个在C - 3位的侧链，即3,5 - 二甲基 - 1,3 - 庚二烯。此外，异嗜色菌素I具有一个γ - 内酯环，而异嗜色菌素II具有2 - 氧代丙基部分而非γ - 内酯环。