Takanami I, Tanana F, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T, Kodaira S
First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Oncology. 1996 Sep-Oct;53(5):392-7. doi: 10.1159/000227594.
The expression of hepatocyte growth factor (HGF) and its receptor, c-Met, was investigated immunohistologically in tissue specimens of patients with a pulmonary adenocarcinoma. The prognosis was significantly worse in the HGF-positive or c-Met-positive patients than in the negative patients. Multivariate analysis showed that c-Met had a significant effect on the prognosis, whereas HGF did not. Our findings suggest that HGF and c-Met play an important role in tumor progression and that c-Met can be a useful prognostic marker for pulmonary adenocarcinomas.
采用免疫组织化学方法研究了肺腺癌患者组织标本中肝细胞生长因子（HGF）及其受体c-Met的表达情况。HGF阳性或c-Met阳性患者的预后明显比阴性患者差。多因素分析显示，c-Met对预后有显著影响，而HGF则无。我们的研究结果表明，HGF和c-Met在肿瘤进展中起重要作用，且c-Met可作为肺腺癌有用的预后标志物。
