Ryan A J, Chang R T, Gisolfi C V
Department of Exercise Science, University of Iowa, Iowa City 52242-1111, USA.
Med Sci Sports Exerc. 1996 Jun;28(6):698-705. doi: 10.1097/00005768-199606000-00009.
We sought to evaluate the effects of exercise and aspirin on gastroduodenal and intestinal permeability. Seven volunteers (age = 29 +/- 3 yr, VO2max = 56.8 +/- 4.1 ml.kg-1.min-1) rested or performed treadmill exercise (60 min at approximately 68% VO2max), with or without aspirin ingestion. Placebo (glucose) or aspirin (1.3 g) was taken the night before and prior to rest or exercise (total 2.6 g). A permeability test solution (approximately 1300 mOsm.kg-1), containing 10 g lactulose (L), 5 g mannitol (M), and 10 g sucrose (S), was ingested prior to rest or exercise. Urinary excretion rates (6.h-1), expressed as a percentage of ingested dose, were used to quantify intestinal (L/M ratio) or gastroduodenal (S) permeability. Ingestion of aspirin before running increased (P < 0.05) intestinal permeability compared to placebo+running and placebo+rest, but not compared to aspirin+rest; mean (+/-SE) values for the L/M ratio were 0.248 +/- 0.046, 0.029 +/- 0.012, 0.012 +/- 0.004, and 0.104 +/- 0.057, respectively. Gastroduodenal permeability following aspirin+running (3.25 +/- 1.21%) was also elevated (P < 0.05) compared to placebo+running (0.43 +/- 0.15%) and placebo+rest (0.24 +/- 0.11%), but not compared to aspirin+rest (0.66 +/- 0.27%). Neither running nor aspirin ingestion was associated with gastrointestinal (GI) complaints. Thus, GI permeability while running can be markedly elevated by aspirin ingestion.
我们试图评估运动和阿司匹林对胃十二指肠及肠道通透性的影响。七名志愿者（年龄 = 29 ± 3岁，最大摄氧量 = 56.8 ± 4.1 ml·kg⁻¹·min⁻¹）进行休息或在跑步机上运动（约68%最大摄氧量下运动60分钟），运动时或运动前服用或不服用阿司匹林。在休息或运动前一晚及当天服用安慰剂（葡萄糖）或阿司匹林（1.3 g）（共2.6 g）。在休息或运动前摄入一种通透性测试溶液（约1300 mOsm·kg⁻¹），其中含有10 g乳果糖（L）、5 g甘露醇（M）和10 g蔗糖（S）。以摄入剂量的百分比表示的尿排泄率（每6小时）用于量化肠道（L/M比值）或胃十二指肠（S）的通透性。与安慰剂+运动和安慰剂+休息相比，跑步前服用阿司匹林会增加（P < 0.05）肠道通透性，但与阿司匹林+休息相比则无差异；L/M比值的平均值（±标准误）分别为0.248 ± 0.046、0.029 ± 0.012、0.012 ± 0.004和0.104 ± 0.057。与安慰剂+运动（0.43 ± 0.15%）和安慰剂+休息（0.24 ± 0.11%）相比，阿司匹林+运动后的胃十二指肠通透性（3.25 ± 1.21%）也有所升高（P < 0.05），但与阿司匹林+休息（0.66 ± 0.27%）相比无差异。跑步和服用阿司匹林均未引发胃肠道不适。因此，跑步时服用阿司匹林可显著提高胃肠道通透性。
