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[塑料与颌面外科中的生物材料]

[Biomaterials in plastic and maxillofacial surgery].

作者信息

Loddé J P

机构信息

Service de Chirurgie Maxillo-Faciale, Centre Hospitalier de Cornouaille, Quimper.

出版信息

Ann Chir Plast Esthet. 1995 Dec;40(6):676-89.

PMID:8787341
Abstract

The major progress in biomaterials over recent years have concerned osteosynthesis, reconstruction and creation of the shapes of bones and soft tissues and gluing. In the authors' field of osteosynthesis, "pure" medical titanium, particularly T40, is perfectly adapted to situations (face, hand) in which the bone constraints are much lower than those encountered in hip and long bone surgery. Two improvements can be recommended: reheated titanium T40 due to its improved ductility; cermets (ceramo-metallic biomaterials) which have an excellent biocompatibility and which allow bone-implant liaisons, particularly for the bony fixation of epithesis supports. Ceramics and coral can be safely used to fill bone defects, in situations with low constraints. Numerous products are available and improve each year. For an equal quality, it is preferable to use the least expensive. Numerous products are available for reconstruction or creation of soft tissues, but present various disadvantages such as collagen, which is not resorbed, collagen-bioceramic, bone-collagen, hydroxyapatite-gelatin composites have a promising future, but the follow-up is too short at the present time. Fluorinated polymers, of which Gore-Tex is the leader, have been used for about thirty years in multiple applications, and certainly have a great future. The technology of biological glues is difficult, but this line of research is very interesting and promising for glues derived from non-living substances.

摘要

近年来生物材料的主要进展涉及骨接合、骨骼和软组织形状的重建与塑造以及粘合。在作者的骨接合领域,“纯”医用钛,特别是T40,非常适用于骨骼约束远低于髋关节和长骨手术的情况(面部、手部)。可以推荐两项改进:重新加热的T40钛因其延展性提高;金属陶瓷(陶瓷 - 金属生物材料)具有出色的生物相容性,可实现骨 - 植入物连接,特别是用于假体支撑的骨固定。在约束较低的情况下,陶瓷和珊瑚可安全用于填充骨缺损。有许多产品可供选择且每年都在改进。对于同等质量的产品,最好使用最便宜的。有许多产品可用于软组织的重建或塑造,但存在各种缺点,例如不可吸收的胶原蛋白、胶原蛋白 - 生物陶瓷、骨 - 胶原蛋白、羟基磷灰石 - 明胶复合材料有广阔的前景,但目前随访时间太短。以戈尔泰斯(Gore-Tex)为首的含氟聚合物已在多种应用中使用了约三十年,肯定有很大前途。生物胶水技术难度大,但这条研究路线对于源自非生物物质的胶水来说非常有趣且前景广阔。

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