Zaffe Davide, Bertoldi Carlo, Consolo Ugo
Department of Anatomy, Section of Human Anatomy, University of Modena and Reggio Emilia, Via del Pozzo 71, Policlinico, 41100 Modena, MO, Italy.
Biomaterials. 2004 Aug;25(17):3837-44. doi: 10.1016/j.biomaterials.2003.10.020.
Titanium plates, Ti6Al4V screws and surrounding tissues, and biopsies of hydroxyapatite (Osprovit) grafts of maxillary sinus lifting were investigated to evaluate the release and accumulation of ions. Optical microscopy, SEM and X-ray microanalysis were carried out to evaluate the plates and screws removed from patients presenting inflammation and biopsies. Ions release from metallic appliances or leaching from granules towards soft tissues was observed. An accumulation of aluminium but not titanium was found in soft tissues. A peculiar accumulation of aluminium in the dense lamella of newly formed bone was recorded. The results seem to indicate that biological perturbations may be related to aluminium release from the tested biomaterials. The aluminium content of these biomaterials, its diffusion and accumulation are discussed. Further studies on ion release from biomaterials and aluminium fate in skeletal tissues are suggested.
研究了钛板、Ti6Al4V螺钉及其周围组织，以及上颌窦提升术的羟基磷灰石（Osprovit）移植物活检样本，以评估离子的释放和积累情况。采用光学显微镜、扫描电子显微镜和X射线微分析对从出现炎症的患者体内取出的钛板、螺钉以及活检样本进行评估。观察到金属器械释放离子或颗粒向软组织浸出离子的现象。在软组织中发现有铝的积累，但未发现钛的积累。记录到在新形成骨的致密板层中有特殊的铝积累现象。结果似乎表明，生物扰动可能与受试生物材料中铝的释放有关。讨论了这些生物材料的铝含量、其扩散和积累情况。建议进一步研究生物材料的离子释放以及铝在骨骼组织中的归宿。
