Goldin L R, Chase G A, King T M, Badner J A, Gershon E S
Clinical Neurogenetics Branch, NIMH, Bethesda, Maryland 20814-1274, USA.
Genet Epidemiol. 1995;12(6):765-9. doi: 10.1002/gepi.1370120639.
We used the Haseman-Elston sib-pair test to screen for linkage of markers to genes for disease susceptibility in the simulated data as given in Problem 2 of GAW9. We applied the analysis to the underlying quantitative liability trait (Q1), other covariates of Q1 (Q2-Q4), and the dichotomous affection status trait. In addition, we analyzed the residual Q1 after adjusting for the covariates. Using the sib-pair linkage test, we identified a large region of chromosome 5 affecting the residual value of Q1, a region of chromosome 2 affecting Q3, and a region of chromosome 1 possibly affecting Q2. The analysis of the dichotomous traits did not reveal any regions to be significant. This is likely to be due to lack of information since the families were not selected through affected probands.
我们使用哈斯曼-埃尔斯顿同胞对检验，对GAW9问题2中给出的模拟数据里的疾病易感性基因标记进行连锁筛选。我们将该分析应用于潜在的定量易患性性状（Q1）、Q1的其他协变量（Q2-Q4）以及二分患病状态性状。此外，我们在对协变量进行调整后分析了Q1的残差。使用同胞对连锁检验，我们确定了5号染色体上一个影响Q1残差值的大区域、2号染色体上一个影响Q3的区域以及1号染色体上一个可能影响Q2的区域。对二分性状的分析未发现任何显著区域。这可能是由于缺乏信息，因为这些家系并非通过患病先证者进行选择。
