Juo S H, Beaty T H, Duffy D L, Maestri N E, Prenger V L, Zeiger J, Lei H H, Coresh J
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Genet Epidemiol. 1997;14(6):815-20. doi: 10.1002/(SICI)1098-2272(1997)14:6<815::AID-GEPI42>3.0.CO;2-Q.
We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.
我们采用描述性分析来研究问题2A中情感状态与五个数量性状（Q1-Q5）之间的关系，结果表明这五个数量性状可分为两组。第一组包括三个高度相关的性状Q1-Q3，它们是情感状态的基础，第二组包括Q4和Q5，它们与情感状态没有直接关系。对第一次重复实验中的性状Q1-Q3和情感状态进行分离和连锁分析，检测到Q1的一个主要基因座（MG1）与5号染色体上的标记14（D5G14）连锁。由于我们的分离分析未能显示出对Q2有主要基因座效应的证据，而且我们忽略了MG3与性别的相互作用，所以我们没有检测到MG2或MG3。使用Haseman-Elston同胞对分析[Haseman和Elston，1972]，我们还在全基因组筛选的背景下，检验了其余199次重复实验中Q1的统计功效和I型错误率（以环境因素为指标）。
