Bek B, Boeckh M, Lepenies J, Bieniek B, Arasteh K, Heise W, Deppermann K M, Bornhöft G, Stöffler-Meilicke M, Schuller I, Höffken G
Division of Cardiopulmonology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
J Clin Microbiol. 1996 Feb;34(2):457-9. doi: 10.1128/jcm.34.2.457-459.1996.
Cytomegalovirus (CMV) antigenemia was evaluated in 174 patients positive for human immunodeficiency virus. Antigenemia could be detected in 96.7% of patients with CMV disease, 76.9% of patients suffering from a relapse of the disease, and 11.4% of asymptomatic patients with CD4 levels of < 100 cells per microliter. No antigenemia was detected in patients with CD4 levels of 250 to 500 cells per microliter. Specificity and the positive predictive value for CMV disease were increased only if more than 5 positive cells per slide were considered. However, CMV disease may also occur in patients with low-grade antigenemia.
对174例人类免疫缺陷病毒阳性患者进行了巨细胞病毒(CMV)抗原血症评估。在96.7%的CMV疾病患者、76.9%的疾病复发患者以及11.4%的CD4水平低于每微升100个细胞的无症状患者中可检测到抗原血症。在CD4水平为每微升250至500个细胞的患者中未检测到抗原血症。仅当每张玻片上有超过5个阳性细胞时,CMV疾病的特异性和阳性预测值才会增加。然而,CMV疾病也可能发生在低级别抗原血症患者中。