Mazzulli T, Rubin R H, Ferraro M J, D'Aquila R T, Doveikis S A, Smith B R, The T H, Hirsch M S
Infectious Disease Unit, Massachusetts General Hospital, Boston.
J Clin Microbiol. 1993 Oct;31(10):2824-7. doi: 10.1128/jcm.31.10.2824-2827.1993.
We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.
我们评估了一种快速免疫过氧化物酶技术,用于检测56名移植受者(117份标本)和36名艾滋病患者(59份标本)外周血中性粒细胞中的巨细胞病毒(CMV)抗原血症。对于检测移植受者的临床CMV感染,抗原血症的敏感性为92%,特异性为98%;对于艾滋病患者,敏感性为100%,特异性为86%。总体而言,与血的空斑试验培养或传统试管培养相比,CMV抗原血症是一种检测临床CMV感染更快速、更敏感的方法。