• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

巨细胞病毒血症：移植受者及艾滋病患者的临床关联

Cytomegalovirus antigenemia: clinical correlations in transplant recipients and in persons with AIDS.

作者信息

Mazzulli T, Rubin R H, Ferraro M J, D'Aquila R T, Doveikis S A, Smith B R, The T H, Hirsch M S

机构信息

Infectious Disease Unit, Massachusetts General Hospital, Boston.

出版信息

J Clin Microbiol. 1993 Oct;31(10):2824-7. doi: 10.1128/jcm.31.10.2824-2827.1993.

DOI:10.1128/jcm.31.10.2824-2827.1993
PMID:8253997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC266028/
Abstract

We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.

摘要

我们评估了一种快速免疫过氧化物酶技术，用于检测56名移植受者（117份标本）和36名艾滋病患者（59份标本）外周血中性粒细胞中的巨细胞病毒（CMV）抗原血症。对于检测移植受者的临床CMV感染，抗原血症的敏感性为92%，特异性为98%；对于艾滋病患者，敏感性为100%，特异性为86%。总体而言，与血的空斑试验培养或传统试管培养相比，CMV抗原血症是一种检测临床CMV感染更快速、更敏感的方法。

相似文献

1
Cytomegalovirus antigenemia: clinical correlations in transplant recipients and in persons with AIDS.巨细胞病毒血症：移植受者及艾滋病患者的临床关联
J Clin Microbiol. 1993 Oct;31(10):2824-7. doi: 10.1128/jcm.31.10.2824-2827.1993.
2
Comparison of PCR and pp65 antigenemia assay with quantitative shell vial culture for detection of cytomegalovirus in blood leukocytes from solid-organ transplant recipients.比较聚合酶链反应（PCR）、pp65抗原血症检测法与定量空斑试验培养法检测实体器官移植受者血液白细胞中巨细胞病毒的情况。
J Clin Microbiol. 1994 Apr;32(4):997-1003. doi: 10.1128/jcm.32.4.997-1003.1994.
3
Cytomegalovirus (CMV) antigenemia assay is more sensitive than shell vial cultures for rapid detection of CMV in polymorphonuclear blood leukocytes.巨细胞病毒（CMV）抗原血症检测在快速检测多形核血白细胞中的CMV方面比空斑试验培养更敏感。
J Clin Microbiol. 1992 Nov;30(11):2822-5. doi: 10.1128/jcm.30.11.2822-2825.1992.
4
[Investigation of cytomegalovirus positivity in the peripheral blood samples of risky patients by shell-vial cell culture, antigenemia test and real-time polymerase chain reaction].[通过空斑小室细胞培养、抗原血症检测及实时聚合酶链反应对高危患者外周血样本中巨细胞病毒阳性情况的调查]
Mikrobiyol Bul. 2011 Apr;45(2):288-95.
5
Comparison of cytomegalovirus antigenemia and culture assays in patients on and off antiviral therapy.接受和未接受抗病毒治疗患者的巨细胞病毒抗原血症与培养检测比较。
J Med Virol. 1999 Sep;59(1):91-7.
6
Association of quantitative cytomegalovirus antigenemia with symptomatic infection in solid organ transplant patients.实体器官移植患者中定量巨细胞病毒抗原血症与症状性感染的关联。
Diagn Microbiol Infect Dis. 1996 Jan;24(1):19-24. doi: 10.1016/0732-8893(95)00248-0.
7
A multisite trial comparing two cytomegalovirus (CMV) pp65 antigenemia test kits, biotest CMV brite and Bartels/Argene CMV antigenemia.一项比较两种巨细胞病毒（CMV）pp65抗原血症检测试剂盒（Biotest CMV brite和Bartels/Argene CMV抗原血症检测试剂盒）的多中心试验。
J Clin Microbiol. 2000 Apr;38(4):1430-3. doi: 10.1128/JCM.38.4.1430-1433.2000.
8
Use of the cytomegalovirus antigenemia (CMV-Ag) assay for the detection of CMV in the blood of AIDS patients.利用巨细胞病毒血症（CMV-Ag）检测法检测艾滋病患者血液中的巨细胞病毒。
Can J Microbiol. 1993 Nov;39(11):1059-65. doi: 10.1139/m93-160.
9
Shell-vial culture and pp65 antigenemia assay in the detection of cytomegalovirus in the first blood sample of renal transplant recipients.肾移植受者首份血样中巨细胞病毒检测的空斑试验培养和 pp65 抗原血症检测
J Med Virol. 1998 Jul;55(3):240-2. doi: 10.1002/(sici)1096-9071(199807)55:3<240::aid-jmv10>3.0.co;2-k.
10
[Comparison of the CMV antigenemia test and CMV-DNA PCR results in solid organ transplant recipients].[实体器官移植受者中巨细胞病毒抗原血症检测与巨细胞病毒DNA聚合酶链反应结果的比较]
Mikrobiyol Bul. 2016 Jan;50(1):44-52. doi: 10.5578/mb.10701.

引用本文的文献

1
Impact of standardized protocols for cytomegalovirus disease prevention in pediatric solid organ transplant recipients.标准化方案对小儿实体器官移植受者巨细胞病毒病预防的影响。
Pediatr Transplant. 2019 Nov;23(7):e13568. doi: 10.1111/petr.13568. Epub 2019 Sep 13.
2
Relationship between pp65 antigenemia levels and real-time quantitative DNA PCR for Human Cytomegalovirus (HCMV) management in immunocompromised patients.免疫功能低下患者中pp65抗原血症水平与人类巨细胞病毒（HCMV）管理的实时定量DNA聚合酶链式反应之间的关系。
BMC Infect Dis. 2007 Nov 23;7:138. doi: 10.1186/1471-2334-7-138.
3
Role of cell culture for virus detection in the age of technology.细胞培养在技术时代病毒检测中的作用。
Clin Microbiol Rev. 2007 Jan;20(1):49-78. doi: 10.1128/CMR.00002-06.
4
Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection.通过分析与抗原检测的相关性验证巨细胞病毒血浆DNA载量测量的临床应用及治疗标准的定义。
J Clin Microbiol. 2004 Apr;42(4):1498-504. doi: 10.1128/JCM.42.4.1498-1504.2004.
5
Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant.母亲、胎儿及新生儿人巨细胞病毒感染的诊断与管理
Clin Microbiol Rev. 2002 Oct;15(4):680-715. doi: 10.1128/CMR.15.4.680-715.2002.
6
Distinguishing cytomegalovirus (CMV) infection and disease with CMV nucleic acid assays.通过巨细胞病毒核酸检测鉴别巨细胞病毒（CMV）感染和疾病。
J Clin Microbiol. 2002 May;40(5):1581-6. doi: 10.1128/JCM.40.5.1581-1586.2002.
7
Comparison of quantitative cytomegalovirus (CMV) PCR in plasma and CMV antigenemia assay: clinical utility of the prototype AMPLICOR CMV MONITOR test in transplant recipients.血浆中巨细胞病毒（CMV）定量聚合酶链反应（PCR）与CMV抗原血症检测的比较：移植受者中AMPLICOR CMV MONITOR检测原型的临床应用
J Clin Microbiol. 2000 Jun;38(6):2122-7. doi: 10.1128/JCM.38.6.2122-2127.2000.
8
Comparison of three assays for cytomegalovirus detection in AIDS patients at risk for retinitis.对有患视网膜炎风险的艾滋病患者进行巨细胞病毒检测的三种检测方法的比较。
J Clin Microbiol. 2000 Feb;38(2):727-32. doi: 10.1128/JCM.38.2.727-732.2000.
9
Value of different assays for detection of human cytomegalovirus (HCMV) in predicting the development of HCMV disease in human immunodeficiency virus-infected patients.不同检测方法在检测人类巨细胞病毒（HCMV）以预测人类免疫缺陷病毒感染患者中HCMV疾病发展方面的价值。
J Clin Microbiol. 2000 Feb;38(2):563-9. doi: 10.1128/JCM.38.2.563-569.2000.
10
Multicenter comparison of the digene hybrid capture CMV DNA assay (version 2.0), the pp65 antigenemia assay, and cell culture for detection of cytomegalovirus viremia.巨细胞病毒血症检测中，第二代Digene杂交捕获法检测巨细胞病毒DNA分析、pp65抗原血症分析及细胞培养法的多中心比较。
J Clin Microbiol. 1999 Apr;37(4):958-63. doi: 10.1128/JCM.37.4.958-963.1999.

本文引用的文献

1
Evaluation of a direct fluorescein-conjugated monoclonal antibody for detection of cytomegalovirus in centrifugation culture.用于检测离心培养中巨细胞病毒的直接荧光素偶联单克隆抗体的评估
J Clin Microbiol. 1987 Aug;25(8):1548-50. doi: 10.1128/jcm.25.8.1548-1550.1987.
2
Detection of cytomegalovirus infections in specimens other than urine by the shell vial assay and conventional tube cell cultures.通过空斑试验和传统的试管细胞培养法检测尿液以外标本中的巨细胞病毒感染。
J Clin Microbiol. 1987 May;25(5):755-7. doi: 10.1128/jcm.25.5.755-757.1987.
3
Comparison of standard tube and shell vial cell culture techniques for the detection of cytomegalovirus in clinical specimens.用于检测临床标本中巨细胞病毒的标准管和细胞培养瓶细胞培养技术的比较。
J Clin Microbiol. 1985 Feb;21(2):217-21. doi: 10.1128/jcm.21.2.217-221.1985.
4
Comparison between viremia and antigenemia for detection of cytomegalovirus in blood.检测血液中巨细胞病毒时病毒血症与抗原血症的比较。
J Clin Microbiol. 1988 Dec;26(12):2531-5. doi: 10.1128/jcm.26.12.2531-2535.1988.
5
Rapid immunodiagnosis of active cytomegalovirus infection by monoclonal antibody staining of blood leucocytes.通过血液白细胞的单克隆抗体染色对活动性巨细胞病毒感染进行快速免疫诊断。
J Med Virol. 1988 Jun;25(2):179-88. doi: 10.1002/jmv.1890250208.
6
Detection of human cytomegalovirus immediate early antigen in leukocytes as a marker of viremia in immunocompromised patients.检测白细胞中人巨细胞病毒即刻早期抗原作为免疫功能低下患者病毒血症的标志物。
J Med Virol. 1989 Oct;29(2):88-93. doi: 10.1002/jmv.1890290204.
7
Cytomegalovirus antigenemia as a useful marker of symptomatic cytomegalovirus infection after renal transplantation--a report of 130 consecutive patients.巨细胞病毒血症作为肾移植后症状性巨细胞病毒感染的有用标志物——130例连续患者的报告
Transplantation. 1989 Dec;48(6):991-5. doi: 10.1097/00007890-198912000-00019.
8
Correlation between immunofluorescent detection of human cytomegalovirus immediate early antigens in polymorphonuclear leukocytes and viremia.
J Infect Dis. 1989 Jul;160(1):159-60. doi: 10.1093/infdis/160.1.159.
9
Cytomegalovirus (CMV) antigenemia: rapid diagnosis and relationship with CMV-associated clinical syndromes in renal allograft recipients.巨细胞病毒（CMV）抗原血症：肾移植受者中CMV相关临床综合征的快速诊断及关系
Transplant Proc. 1989 Feb;21(1 Pt 2):2061-4.
10
Cytomegalovirus antigenemia.
Rev Infect Dis. 1990 Sep-Oct;12 Suppl 7:S734-44.