Scaiano J C
Department of Chemistry, University of Ottawa, Ontario, Canada.
J Pineal Res. 1995 Nov;19(4):189-95. doi: 10.1111/j.1600-079x.1995.tb00188.x.
Melatonin is an excellent free radical scavenger, reacting with tert-butoxyl and cumyloxyl radicals with rate constants of 3.4 x 10(7) and 6.7 x 10(7) M-1s-1, respectively. Reaction with benzophenone triplet occurs with a near-diffusion-controlled rate constant of 7.6 x 10(9) M-1s-1 in acetonitrile and probably involves charge transfer. When the radical pair formed by reaction of benzophenone triplet and melatonin is sequestered in a micelle, it is subject to extensive magnetic field effects that can be readily interpreted by the radical pair model.
褪黑素是一种出色的自由基清除剂，它与叔丁氧基自由基和枯基氧基自由基反应，速率常数分别为3.4×10⁷和6.7×10⁷ M⁻¹s⁻¹。在乙腈中，它与二苯甲酮三线态的反应速率常数接近扩散控制，为7.6×10⁹ M⁻¹s⁻¹，且可能涉及电荷转移。当二苯甲酮三线态与褪黑素反应形成的自由基对被隔离在胶束中时，它会受到广泛的磁场效应影响，而这种效应可以通过自由基对模型很容易地解释。
