Yaziji H, Broghamer W L
Department of Pathology, University of Louisville Hospital, Louisville, Ky, USA.
South Med J. 1996 Sep;89(9):921-4. doi: 10.1097/00007611-199609000-00016.
Primary small cell undifferentiated carcinomas (SCUCs) are unusual tumors of the colon and rectum. Histologically, these lesions represent a spectrum of neuroendocrine differentiation, with oat cell carcinoma being the most primitive subtype and carcinoid tumors being the most differentiated. This observation is supported by immunohistochemical and ultrastructural findings. We report a case of SCUC of the rectum in a patient with ulcerative colitis. To date, there have been only two reported cases of primary SCUC associated with ulcerative colitis. Recent theories of tumorigenesis attribute most colorectal cancers to a single, pluripotential mucosal stem cell, regardless of the tumor's histologic type.
原发性小细胞未分化癌（SCUCs）是结肠和直肠的罕见肿瘤。从组织学上看，这些病变代表了一系列神经内分泌分化，其中燕麦细胞癌是最原始的亚型，类癌肿瘤是分化程度最高的。这一观察结果得到了免疫组织化学和超微结构研究结果的支持。我们报告了1例溃疡性结肠炎患者发生直肠SCUC的病例。迄今为止，仅有2例原发性SCUC与溃疡性结肠炎相关的病例报道。最近的肿瘤发生理论认为，大多数结直肠癌都起源于单个多能黏膜干细胞，而与肿瘤的组织学类型无关。
