• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

溃疡性结肠炎相关小细胞癌——新的治疗选择：病例报告。

Small cell carcinoma in ulcerative colitis--new treatment option: a case report.

机构信息

Department of Surgery, Interbalkan European Medical Center, Thessaloniki, Greece.

出版信息

World J Surg Oncol. 2010 Nov 18;8:100. doi: 10.1186/1477-7819-8-100.

DOI:10.1186/1477-7819-8-100
PMID:21087512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2999595/
Abstract

BACKGROUND

The most common type of carcinoma associated with ulcerative colitis (UC) is adenocarcinoma. We present a case of primary rectal small cell carcinoma in a patient with a history of UC.

METHODS

A 34-year-old male diagnosed with UC for 10 years was not consistent with the usual annual follow-up and presented with mucoid-bloody diarrhea. Colonoscopy revealed a rectal mass 2 cm distant from the anal verge. The patient underwent a total proctocolectomy with preservation of the anal sphincters, construction of an ileal reservoir, anastomosis of the reservoir to the anus (J configuration) and protective loop ileostomy.

RESULTS

Histological examination showed undifferentiated small cell carcinoma.

CONCLUSIONS

This is the first case of small cell carcinoma in a background of UC reported to be treated surgically and the patient and has no recurrence 18 months postoperatively.

摘要

背景

与溃疡性结肠炎（UC）相关的最常见的癌为腺癌。我们报告了一例 UC 病史患者的原发性直肠小细胞癌。

方法

一名 34 岁男性，UC 病史 10 年，未进行常规年度随访，出现黏液脓血便。结肠镜检查显示距肛门 2cm 处直肠有一肿块。患者接受了全直肠结肠切除术，保留肛门括约肌，行回肠储袋构建，储袋与肛门（J 型）吻合，并保护性回肠造口术。

结果

组织学检查显示未分化小细胞癌。

结论

这是首例报道的 UC 背景下的小细胞癌经手术治疗的病例，患者术后 18 个月无复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1c8c903374e7/1477-7819-8-100-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1d9d755eaabf/1477-7819-8-100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/d1aaac189364/1477-7819-8-100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1513b995f089/1477-7819-8-100-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/4a2735c0c4f3/1477-7819-8-100-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/3ecefdab3fe3/1477-7819-8-100-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/db308097ad33/1477-7819-8-100-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/fdbb188b43de/1477-7819-8-100-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/5e0caaac501d/1477-7819-8-100-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1c8c903374e7/1477-7819-8-100-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1d9d755eaabf/1477-7819-8-100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/d1aaac189364/1477-7819-8-100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1513b995f089/1477-7819-8-100-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/4a2735c0c4f3/1477-7819-8-100-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/3ecefdab3fe3/1477-7819-8-100-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/db308097ad33/1477-7819-8-100-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/fdbb188b43de/1477-7819-8-100-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/5e0caaac501d/1477-7819-8-100-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a0/2999595/1c8c903374e7/1477-7819-8-100-9.jpg

相似文献

1
Small cell carcinoma in ulcerative colitis--new treatment option: a case report.溃疡性结肠炎相关小细胞癌——新的治疗选择：病例报告。
World J Surg Oncol. 2010 Nov 18;8:100. doi: 10.1186/1477-7819-8-100.
2
Surgical resections of ulcerative colitis associated with dysplasia or carcinoma.对伴有发育异常或癌的溃疡性结肠炎进行手术切除。
World J Surg Oncol. 2015 Feb 21;13:70. doi: 10.1186/s12957-015-0499-4.
3
Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for Peutz-Jeghers syndrome with synchronous rectal cancer.腹腔镜保留直肠全结肠切除术加回肠贮袋肛管吻合术治疗黑斑息肉综合征合并同时性直肠癌
World J Gastroenterol. 2016 Jun 14;22(22):5293-6. doi: 10.3748/wjg.v22.i22.5293.
4
[Adenocarcinoma following restorative proctocolectomy for ulcerative colitis: a case report and review of the literature].[溃疡性结肠炎行保留直肠结肠切除术术后腺癌：一例病例报告及文献复习]
G Chir. 2007 Oct;28(10):371-6.
5
Ulcerative colitis associated with nephrotic syndrome after treatment with mesalazine developed into rectal carcinoma: a case study.美沙拉嗪治疗后溃疡性结肠炎合并肾病综合征发展为直肠癌：一例病例报告
World J Surg Oncol. 2016 Jul 22;14(1):192. doi: 10.1186/s12957-016-0950-1.
6
Anal transitional zone adenocarcinoma following restorative proctocolectomy for ulcerative colitis: case report and review of literature.
Acta Gastroenterol Belg. 2009 Oct-Dec;72(4):441-3.
7
A young woman who developed ascending colon cancer 2 years after the onset of ulcerative colitis.一位年轻女性在溃疡性结肠炎发病 2 年后发展为升结肠癌。
Clin J Gastroenterol. 2020 Dec;13(6):1189-1195. doi: 10.1007/s12328-020-01207-3. Epub 2020 Aug 11.
8
Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis.溃疡性结肠炎行双吻合器回肠储袋肛管吻合术后肛管移行区腺癌
Colorectal Dis. 2008 Jul;10(6):621-3. doi: 10.1111/j.1463-1318.2007.01402.x. Epub 2007 Oct 19.
9
Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case.一名溃疡性结肠炎患者在回肠J形贮袋切除术后11年直肠残端发生腺癌：病例报告
Dis Colon Rectum. 2008 Jul;51(7):1146-8. doi: 10.1007/s10350-008-9238-z. Epub 2008 Apr 25.
10
Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis.回肠贮袋炎相关异型增生和腺癌发生于溃疡性结肠炎的直肠结肠切除术后。
Tech Coloproctol. 2011 Mar;15(1):7-16. doi: 10.1007/s10151-010-0664-2. Epub 2011 Feb 2.

引用本文的文献

1
A Mixed Neuroendocrine/Non-Neuroendocrine Neoplasm Arising in the Background of Ulcerative Colitis: A Case Report and Review of the Literature.溃疡性结肠炎背景下发生的混合性神经内分泌/非神经内分泌肿瘤：病例报告及文献复习。
Am J Case Rep. 2022 Mar 3;23:e934396. doi: 10.12659/AJCR.934396.
2
Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis.一名溃疡性结肠炎患者发生异时性转移性结肠小细胞癌和复发性腺癌。
J Surg Case Rep. 2017 Oct 20;2017(10):rjx201. doi: 10.1093/jscr/rjx201. eCollection 2017 Oct.
3
Radiation therapy improves survival in rectal small cell cancer - Analysis of Surveillance Epidemiology and End Results (SEER) data.

本文引用的文献

1
Small cell carcinoma occurring in a case of ulcerative colitis.
Trop Gastroenterol. 2008 Oct-Dec;29(4):224-6.
2
Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies.溃疡性结肠炎患者患结直肠癌的风险：变化、成因及管理策略
World J Gastroenterol. 2008 Jul 7;14(25):3937-47. doi: 10.3748/wjg.14.3937.
3
The effectiveness of chemotherapy with cisplatin and 5-fluorouracil for recurrent small cell neuroendocrine carcinoma of the rectum: report of a case.顺铂和5-氟尿嘧啶化疗对复发性直肠小细胞神经内分泌癌的疗效：病例报告
放射治疗可提高直肠小细胞癌的生存率——监测、流行病学和最终结果（SEER）数据分析
Radiat Oncol. 2015 Apr 24;10:101. doi: 10.1186/s13014-015-0411-y.
4
A case of primary colonic small-cell carcinoma arising in a patient with long-standing ulcerative colitis.一名患有长期溃疡性结肠炎的患者发生原发性结肠小细胞癌的病例。
Gastrointest Cancer Res. 2014 May;7(3-4):119-22.
Surg Today. 1999;29(2):165-9. doi: 10.1007/BF02482243.
4
Primary small cell undifferentiated carcinoma of the rectum associated with ulcerative colitis.直肠原发性小细胞未分化癌伴溃疡性结肠炎
South Med J. 1996 Sep;89(9):921-4. doi: 10.1097/00007611-199609000-00016.
5
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.炎症性肠病中的发育异常：标准化分类及临时临床应用
Hum Pathol. 1983 Nov;14(11):931-68. doi: 10.1016/s0046-8177(83)80175-0.
6
Small-cell undifferentiated carcinoma of the colon. A clinicopathological study of five cases and their association with colonic adenomas.
Am J Surg Pathol. 1983 Oct;7(7):643-51. doi: 10.1097/00000478-198310000-00005.
7
Neuroendocrine tumors of the gastrointestinal tract.胃肠道神经内分泌肿瘤
Pathol Res Pract. 1988 Apr;183(2):143-54. doi: 10.1016/S0344-0338(88)80042-6.
8
Stem cell carcinoma of the colon and rectum. Report of two cases and review of the literature.
Dis Colon Rectum. 1985 Jun;28(6):440-5. doi: 10.1007/BF02560233.
9
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma.
Hum Pathol. 1987 Jan;18(1):9-21. doi: 10.1016/s0046-8177(87)80187-9.
10
Neuroendocrine carcinoma of the colon and rectum. A clinicopathologic, ultrastructural, and immunohistochemical study of 24 cases.结肠和直肠神经内分泌癌。24例临床病理、超微结构及免疫组化研究
Am J Surg Pathol. 1990 Nov;14(11):1010-23. doi: 10.1097/00000478-199011000-00003.