Humphries T J, Castell D O
Am J Dig Dis. 1977 Jul;22(7):641-5. doi: 10.1007/BF01073085.
The pressure profile of esophageal peristalsis was studied in healthy young adult males using an intraesophageal transducer assembly. The amplitude of peristaltic contractions following wet swallows was determined at intervals along the esophagus from the lower esophageal sphincter (LES) to the upper esophageal sphincter (UES). The amplitude profile revealed a trough of significantly decreased (P less than 0.05) amplitude at 17.5-20.0 cm above the LES. The change in pressure per unit time (dp/dt) produced a profile also with a significant decrease (P less than 0.01) in the upper esophagus, having good correlation (r = 0.91, P less than 0.001) with the amplitude profile. Mean velocity of the peristaltic wave in the upper esophagus varied from 2.92 +/- 0.19 (+/- SEM) to 3.29 +/- 0.36 cm/sec. In the distal esophagus, mean velocity increased significantly (P less than 0.01) to 4.98 +/- 0.38 cm/sec at 7.5 cm above the LES, and then fell significantly (P less than 0.05) to 2.15 +/- 0.27 cm/sec at 2.5 cm above the LES. This report establishes amplitude and velocity profiles in the human esophagus. The profile of the first derivative of the primary peristaltic wave (dp/dt) is also described, and its possible importance discussed.
使用食管内换能器组件对健康年轻成年男性的食管蠕动压力曲线进行了研究。在从食管下括约肌（LES）到食管上括约肌（UES）的食管沿线间隔处，测定了湿吞咽后蠕动收缩的幅度。幅度曲线显示，在LES上方17.5 - 20.0厘米处存在幅度显著降低（P < 0.05）的波谷。单位时间内的压力变化（dp/dt）产生的曲线在食管上段也有显著降低（P < 0.01），与幅度曲线具有良好的相关性（r = 0.91，P < 0.001）。食管上段蠕动波的平均速度在2.92 ± 0.19（±SEM）至3.29 ± 0.36厘米/秒之间变化。在食管远端，平均速度在LES上方7.5厘米处显著增加（P < 0.01）至4.98 ± 0.38厘米/秒，然后在LES上方2.5厘米处显著下降（P < 0.05）至2.15 ± 0.27厘米/秒。本报告确立了人类食管的幅度和速度曲线。还描述了原发性蠕动波的一阶导数（dp/dt）曲线，并讨论了其可能的重要性。
