Mee J F, O'Farrell K J, Reitsma P, Mehra R
Teagasc, Moorepark Research Centre, Fermoy, County Cork, Ireland.
J Dairy Sci. 1996 May;79(5):886-94. doi: 10.3168/jds.S0022-0302(96)76437-8.
The efficacy of a whey protein concentrate was evaluated as a colostrum substitute or supplement in two experiments using four groups of 29 calves. In Experiment 1, calves were fed either 2 L of pooled colostrum (group 1) or 500 g of whey protein concentrate (group 2). A mean total of 123.6 and 17.7 g of Ig was fed to calves in groups 1 and 2, respectively. Mean serum IgG, total protein, and globulin concentrations and Ig antibody activities to Escherichia coli K99 and rotavirus were significantly higher for calves in group 1 at 24 to 36 h and at 3 wk of age. Weight gain from birth to 3 wk of age was significantly lower for calves in group 2. The incidence of diarrhea was high but not different between treatments. The mortality rate (0 to 3 wk) was significantly higher for calves in group 2 (27.6%) than for calves in group 1 (3.4%). In Experiment 2, calves were fed either 2 L of pooled colostrum (group 3) or a solution of 1 L of pooled colostrum plus 500 g of whey protein concentrate (group 4). A mean total of 117.2 and 69.1 g of Ig was fed to calves in groups 3 and 4, respectively. Absorption rate of IgG was significantly lower for calves in group 4. Mean serum IgG, total protein, and globulin concentrations and Ig antibody activities to E. coli K99 and rotavirus were significantly higher for calves in group 3 at 24 to 36 h and at 3 wk of age. Mortality rate, BW gain, and incidence of diarrhea did not differ significantly between groups.
在两项实验中，使用四组共29头犊牛评估了浓缩乳清蛋白作为初乳替代品或补充剂的功效。在实验1中，犊牛分别饲喂2升混合初乳（第1组）或500克浓缩乳清蛋白（第2组）。第1组和第2组犊牛摄入的免疫球蛋白（Ig）平均总量分别为123.6克和17.7克。在24至36小时以及3周龄时，第1组犊牛的血清IgG、总蛋白和球蛋白浓度以及针对大肠杆菌K99和轮状病毒的Ig抗体活性显著更高。第2组犊牛从出生到3周龄的体重增加显著更低。腹泻发生率很高，但各处理组之间没有差异。第2组犊牛的死亡率（0至3周）显著高于第1组（27.6%比3.4%）。在实验2中，犊牛分别饲喂2升混合初乳（第3组）或1升混合初乳加500克浓缩乳清蛋白的溶液（第4组）。第3组和第4组犊牛摄入的Ig平均总量分别为117.2克和69.1克。第4组犊牛的IgG吸收率显著更低。在24至36小时以及3周龄时，第3组犊牛的血清IgG、总蛋白和球蛋白浓度以及针对大肠杆菌K99和轮状病毒的Ig抗体活性显著更高。两组之间的死亡率、体重增加和腹泻发生率没有显著差异。
