Matsui D, Barron A, Rieder M J
Department of Pediatrics, University of Western Ontario, London, Canada.
Ann Pharmacother. 1996 Jun;30(6):586-8. doi: 10.1177/106002809603000603.
To evaluate the palatability of four commonly prescribed antistaphylococcal antibiotics, cloxacillin, cephalexin, erythromycin, and fusidic acid, in volunteer children.
A single-blind taste test of four flavored antibiotic suspensions commonly used in the treatment of skin infections in pediatric patients.
University teaching hospital.
Twenty healthy volunteer children with a mean age of 9.2 +/- 2.0 SD years (range 6-12).
The taste of each antibiotic was rated by the children on a 10-cm visual analog scale incorporating a facial hedonic scale. The children were also asked which antibiotic they thought tasted the best and which tasted the worst.
Taste scores were as follows: cloxacillin 1.4 +/- 1.8 cm, cephalexin 6.5 +/- 2.7 cm, erythromycin 6.8 +/- 3.0 cm, and fusidic acid 6.3 +/- 2.4 cm. The taste rating of cloxacillin was significantly lower compared with the other three antibiotics (p = 0.001). Cloxacillin was chosen as having the worst taste by a significant proportion of the children (18 of 20). None of the antibiotics was clearly best tasting.
Given similar effectiveness, taste considerations may be important in the decision as to which antibiotic to prescribe. The perception that cloxacillin is poor tasting to children is supported by this study, which suggests that when compliance with oral medication is critical for successful treatment, prescription of cloxacillin suspension should be avoided.
评估四种常用的抗葡萄球菌抗生素——氯唑西林、头孢氨苄、红霉素和夫西地酸在儿童志愿者中的适口性。
对四种常用于治疗儿科患者皮肤感染的调味抗生素混悬液进行单盲味觉测试。
大学教学医院。
20名健康儿童志愿者，平均年龄9.2±2.0标准差岁（范围6 - 12岁）。
孩子们根据包含面部享乐量表的10厘米视觉模拟量表对每种抗生素的味道进行评分。还询问孩子们认为哪种抗生素味道最好，哪种味道最差。
味道评分如下：氯唑西林1.4±1.8厘米，头孢氨苄6.5±2.7厘米，红霉素6.8±3.0厘米，夫西地酸6.3±2.4厘米。氯唑西林的味道评分明显低于其他三种抗生素（p = 0.001）。相当一部分孩子（20人中的18人）认为氯唑西林味道最差。没有一种抗生素的味道明显最好。
在疗效相似的情况下，口味因素在决定使用哪种抗生素时可能很重要。本研究支持了氯唑西林对儿童来说味道不佳的观点，这表明当口服药物的依从性对成功治疗至关重要时，应避免开具氯唑西林混悬液的处方。
