El-Chaar G M, Mardy G, Wehlou K, Rubin L G
St. John's University College of Pharmacy, Jamaica, NY, USA.
Pediatr Infect Dis J. 1996 Jan;15(1):18-22. doi: 10.1097/00006454-199601000-00004.
The taste of oral liquid medications influences compliance in children. Generic preparations are prescribed to reduce cost and may taste worse than brand name products.
This was a prospective, randomized, double blind, crossover trial of the differences in taste and compliance between brand and generic antibiotic suspensions in children 3 to 14 years of age. Verbal and visual assessment methods were used to assess taste, and compliance was measured by the amount of drug returned after use.
Ten children in each of the cephalexin and erythromycin-sulfisoxazole groups did not report that the brand and generic formulations tasted differently. Fifteen children thought that brand trimethoprim-sulfamethoxazole tasted better than the generic preparation.
Brand name oral liquid antibiotics do not necessarily taste better than their generic counterparts. Despite preference for the taste of brand trimethoprim-sulfamethoxazole, all of the children in this study were compliant with both brand and generic medications.
口服液体制剂的味道会影响儿童的用药依从性。开具通用制剂是为了降低成本，但其味道可能比品牌产品更差。
这是一项前瞻性、随机、双盲、交叉试验，旨在研究3至14岁儿童使用品牌和通用抗生素混悬液时味道和依从性的差异。采用口头和视觉评估方法来评估味道，并通过使用后剩余的药量来衡量依从性。
头孢氨苄组和红霉素-磺胺异恶唑组各有10名儿童未报告品牌制剂和通用制剂的味道有差异。15名儿童认为品牌的甲氧苄啶-磺胺甲恶唑味道比通用制剂更好。
品牌口服液体抗生素的味道不一定比其通用制剂更好。尽管儿童更喜欢品牌的甲氧苄啶-磺胺甲恶唑的味道，但本研究中的所有儿童对品牌和通用药物的依从性都很好。
