Ardévol A, Adán C, Remesar X, Alemany M, Fernández-López J A
Department de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain.
Arch Physiol Biochem. 1996;104(3):337-43. doi: 10.1076/apab.104.3.337.12894.
Tissue blood flow has been measured in Zucker lean and obese rats during treadmill exercise and later recovery, by using a fluorescent-dyed latex microsphere method. The procedure used allowed up to six different timed blood flow measurements in the same animal. Exercise resulted in grossly increased muscle blood flow, compensated by lowered intestinal and liver irrigation. At the onset of fatigue, and during early recovery, liver portal blood flow increased in detriment of muscle. Obese rats showed a similar pattern, but their intestinal and hepatic blood flow was maintained during recovery, in contrast with lean rats. In obese - but not in lean - rats, skin blood flow increased in post-exercise recovery to disposal of excess heat hampered by blubber insulation. Metabolic inability to recover markedly affects post-exercise haemodynamics in Zucker obese rats, thus prolonging the consequences of fatigue.
通过使用荧光染料标记的乳胶微球法，对正常体重和肥胖的 Zucker 大鼠在跑步机运动期间及随后的恢复过程中的组织血流进行了测量。所采用的方法允许在同一只动物身上进行多达六次不同时间的血流测量。运动导致肌肉血流显著增加，同时肠道和肝脏灌注减少以作补偿。在疲劳开始时以及早期恢复过程中，肝门静脉血流增加，肌肉血流减少。肥胖大鼠呈现出类似的模式，但与正常体重大鼠不同的是，它们在恢复过程中肠道和肝脏血流得以维持。在肥胖大鼠（而非正常体重大鼠）中，运动后恢复期间皮肤血流增加，以处置因脂肪隔热而阻碍的多余热量。代谢恢复能力的显著下降明显影响了 Zucker 肥胖大鼠运动后的血流动力学，从而延长了疲劳的影响。
