Hansenne M, Pitchot W, Gonzalez Moreno A, Zaldua I U, Ansseau M
Psychiatric Unit, CHU André Vésale, Montigny-Le-Tilleul, Belgium.
Biol Psychiatry. 1996 Jul 15;40(2):116-22. doi: 10.1016/0006-3223(95)00372-x.
P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results showed a significant reduction of P200, P300, and CNV and a significant increase of postimperative negative variation (PINV) in patients who had attempted suicide compared to patients with a negative history. Moreover, P300 amplitude was negatively related with the Suicidal Risk and the Hopelessness but not with the Hamilton scales. These results stress the need to differentiate clinical subgroups of patients to assess the psychophysiology of depression, and indicate that patients who attempted suicide exhibit lower cortical resources and poorer cortical performance than patients without history of suicide attempt.
对有和没有自杀未遂史的抑郁症住院患者记录了P300和关联性负变（CNV）。结果显示，与无自杀史的患者相比，有自杀未遂史的患者的P200、P300和CNV显著降低，指令后负变（PINV）显著增加。此外，P300波幅与自杀风险和绝望感呈负相关，但与汉密尔顿量表无关。这些结果强调了区分患者临床亚组以评估抑郁症心理生理学的必要性，并表明有自杀未遂史的患者比无自杀未遂史的患者表现出更低的皮质资源和更差的皮质功能。
