Passaro K T, Little R E, Savitz D A, Noss J
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA.
Epidemiology. 1996 Jul;7(4):377-83. doi: 10.1097/00001648-199607000-00007.
We examined the association of maternal drinking before and during early pregnancy on infant birthweight, using data collected from a population-based cohort in Avon Country, England. Participants completed several self-administered questionnaires during their index pregnancy. Our analysis included 10,539 women who provided drinking data and delivered a liveborn singleton child. Infants born to women who reported drinking one to two drinks daily with at least one binge, or three or more drinks daily with or without binges, had an adjusted mean birthweight approximately 150 gm less than that of infants whose mothers reported abstaining during (but not before) pregnancy. Mean birthweights were similar for infants of prepregnancy drinkers who drank weekly in early pregnancy, less than weekly, or not at all.
我们利用从英国埃文郡一项基于人群的队列研究中收集的数据，研究了孕早期及孕前期母亲饮酒与婴儿出生体重之间的关联。参与者在其本次孕期完成了几份自行填写的问卷。我们的分析纳入了10539名提供饮酒数据并分娩出单胎活产婴儿的女性。报告每日饮酒1至2杯且至少有一次暴饮，或每日饮酒3杯及以上（无论有无暴饮）的女性所生婴儿，其校正后的平均出生体重比母亲报告在孕期（而非孕前期）戒酒的女性所生婴儿轻约150克。孕前期饮酒且在孕早期每周饮酒、少于每周饮酒或根本不饮酒的女性所生婴儿的平均出生体重相似。
