Little R E, Sing C F
Department of Epidemiology, University of Washington, Seattle 98195.
Teratology. 1987 Aug;36(1):59-65. doi: 10.1002/tera.1420360109.
Parents' drinking in the month prior to conception was ascertained for 377 infants born to members of a health maintenance organization. If the father had an average of two or more drinks daily, or had at least five drinks on one occasion, a decrease of 137 gm in infant birth weight was predicted, by means of regression analysis. This result was independent of maternal drinking, although infants whose mothers were regular drinkers weighed less at birth. The lower mean birth weights of infants of regular-drinking fathers was not due to parents' smoking, maternal use of caffeine, marijuana, or other drugs, or 21 other measured variables. This is the first report of an association in humans between father's drinking prior to conception and decreased infant birth weight. However, interpretation of this finding is difficult because the biological mechanisms that might underlie it are obscure.
对一家健康维护组织成员所生的377名婴儿，确定了其父母在受孕前一个月的饮酒情况。通过回归分析预测，如果父亲平均每天饮酒两杯或更多，或曾有过一次至少饮用五杯的情况，婴儿出生体重将减少137克。这一结果与母亲饮酒无关，不过母亲经常饮酒的婴儿出生时体重较轻。父亲经常饮酒的婴儿平均出生体重较低并非由于父母吸烟、母亲使用咖啡因、大麻或其他药物，也与其他21个测量变量无关。这是关于人类受孕前父亲饮酒与婴儿出生体重降低之间关联的首份报告。然而，由于可能作为其基础的生物学机制尚不清楚，对这一发现的解读存在困难。
