Tolo K A, Little R E
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor.
Epidemiology. 1993 Sep;4(5):415-20. doi: 10.1097/00001648-199309000-00006.
We investigated the effects of occasional alcohol binges on birth outcomes in a cohort of live singletons born to 709 moderate drinkers recruited from a Seattle, WA, health maintenance organization before their sixth month of pregnancy. We compared infants of women with one or more binges in the month before pregnancy or in the first two trimesters with those whose mothers reported no binges in either period. Mean values of birthweight, length, head circumference, gestational age, intrauterine growth, and Apgar scores did not differ notably between the two groups. The risk of having an adverse neonatal discharge diagnosis initially appeared lower in infants of binging mothers, but this difference vanished after recategorization of the variable and control for confounding. Our results indicate that occasional binges, during a broad window of exposure and among otherwise moderate drinkers, do not adversely affect the birth outcomes examined here.
我们调查了偶尔酗酒对出生结局的影响，研究对象是从华盛顿州西雅图一家健康维护组织招募的709名中度饮酒者所生的单胎活产婴儿队列，这些孕妇在怀孕6个月前入组。我们将在怀孕前一个月或孕早期有一次或多次酗酒的女性所生婴儿，与母亲报告在这两个时期均无酗酒的婴儿进行了比较。两组之间出生体重、身长、头围、孕周、宫内生长情况和阿氏评分的平均值没有显著差异。酗酒母亲所生婴儿最初出现不良新生儿出院诊断的风险似乎较低，但在对变量进行重新分类并控制混杂因素后，这种差异消失了。我们的结果表明，在广泛暴露期间且其他方面为中度饮酒者中，偶尔酗酒不会对这里所研究的出生结局产生不利影响。
