Lewis J
Department of Zoology, University of Oxford, UK.
Curr Opin Neurobiol. 1996 Feb;6(1):3-10. doi: 10.1016/s0959-4388(96)80002-x.
The neurogenic genes of the Delta-Notch signalling pathway mediate lateral inhibition--a mechanism that controls cell commitment in many tissues and serves in the developing nervous system to single out cells for a neural fate. Recent work has revealed the outlines of the signal transduction pathway from Notch to the nucleus, has clarified the mechanisms by which lateral inhibition causes adjacent cells to become different, and has shown that vertebrates use essentially the same lateral inhibition machinery as flies and worms to regulate neurogenesis.
Delta-Notch信号通路的神经源性基因介导侧向抑制——这是一种在许多组织中控制细胞分化的机制，在发育中的神经系统中用于挑选出具有神经命运的细胞。最近的研究揭示了从Notch到细胞核的信号转导途径的轮廓，阐明了侧向抑制使相邻细胞变得不同的机制，并表明脊椎动物使用与果蝇和线虫基本相同的侧向抑制机制来调节神经发生。
