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耳聋的遗传学

Genetics of deafness.

作者信息

Steel K P, Brown S D

机构信息

MRC Institute of Hearing Research, University of Nottingham, University Park, NG7 2RD, UK.

出版信息

Curr Opin Neurobiol. 1996 Aug;6(4):520-5. doi: 10.1016/s0959-4388(96)80059-6.

Abstract

The genetics of deafness is a rapidly expanding area of research. A remarkable total of twenty-two genes involved in non-syndromic deafness in humans have been localized within the past two years, compared with only one known previously. Some of the genes involved in neuroepithelial deafness, the most common type of pathology, have been identified in the past year. Two of these genes encode unconventional myosin molecules. The roles of these and other molecules identified by genetic approaches as important in hearing are being explored.

摘要

耳聋遗传学是一个迅速发展的研究领域。在过去两年中,共有22个与人类非综合征性耳聋相关的基因被定位,相比之下,之前仅知道一个。在过去一年里,已经确定了一些与神经上皮性耳聋(最常见的病理类型)相关的基因。其中两个基因编码非常规肌球蛋白分子。通过遗传学方法确定的这些分子以及其他在听力中起重要作用的分子的作用正在被探索。

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